Difference between revisions of "Glutamate dehydrogenase"
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[[File:NationWide Logo.jpeg|right|link=https://www.nwlabs.co.uk/|alt=NationWide Logo|240x240px|In Partnership with NationWide Laboratories|frameless|thumb|]] | [[File:NationWide Logo.jpeg|right|link=https://www.nwlabs.co.uk/|alt=NationWide Logo|240x240px|In Partnership with NationWide Laboratories|frameless|thumb|]] | ||
== GLDH Introduction == | == GLDH Introduction == | ||
| − | + | Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity. | |
| − | === | + | === Small Animals === |
| − | ==== | + | ==== Causes of increased GLDH activity ==== |
| − | * | + | * Hepatocellular necrosis |
| − | * | + | * Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology) |
| − | ==== | + | ==== Complementary tests ==== |
| − | + | ALT, albumin, bilirubin and bile acids. | |
| − | === | + | === Equine === |
| − | + | GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, [[Aspartate aminotransferase|AST]] and [[Gamma-glutamyltransferase|GGT]]. Elevated levels therefore indicate active hepatocellular damage. | |
==== Causes of increased GLDH activity ==== | ==== Causes of increased GLDH activity ==== | ||
| − | * | + | * Hepatocellular necrosis |
| − | * | + | * Enteropathy – common and levels can be quite high |
| − | ==== | + | ==== Complementary tests ==== |
| − | + | [[Aspartate aminotransferase|AST]], [[Gamma-glutamyltransferase|GGT]] (hepatocellular damage) and bile acids (hepatic function). | |
== Authors & References == | == Authors & References == | ||
[[NationWide Laboratories]] | [[NationWide Laboratories]] | ||
Revision as of 13:28, 25 March 2022
GLDH Introduction
Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.
Small Animals
Causes of increased GLDH activity
- Hepatocellular necrosis
- Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology)
Complementary tests
ALT, albumin, bilirubin and bile acids.
Equine
GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, AST and GGT. Elevated levels therefore indicate active hepatocellular damage.
Causes of increased GLDH activity
- Hepatocellular necrosis
- Enteropathy – common and levels can be quite high
Complementary tests
AST, GGT (hepatocellular damage) and bile acids (hepatic function).