Difference between revisions of "Category:Liver - Developmental Pathology"

Revision as of 12:05, 7 June 2010

JAVMA paper

Portal hypertension
Sustained impairment of forward venous flow anywhere along the path from the portal vein to the right side of the heart.
Luminal (thrombosis, parasites) or extraluminal obstruction (hepatic fibrosis or nodular regeneration) or relative restriction of flow due to massive portal volume overload (arterioportal fistulas).
Hepatomegaly associated with posthepatic obstruction
Microhepatica – associated with prehepatic/hepatic causes.
Hepatic encephalopathy and GI bleeding not associated with posthepatic causes.
Most common causes are RHS heart failure and severe diffuse hepatobiliary disease that results in cirrhosis.

The following 9 pages are in this category, out of 9 total.

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 == [[Portosystemic Shunt]] ==
-== Hepatic microvascular dysplasia ==
+== [[Hepatic Microvascular Dysplasia]] ==
-*Small intrahepatic portal vessels and portal endothelial hyperplasia which allows abnormal communication between portal and systemic circulation.
-*Can develop as a separate entity or in conjunction with a portosystemic shunt.
-*Can cause c/s similar to those of PSS.
-*[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]], [[Diarrhoea|diarrhoea]], [[Urinary System - Anatomy & Physiology|urinary tract]] changes associated with ammonium biurate urolithiasis, stunted growth, prolonged recovery from anesthesia.
-*Average age of presentation =3yrs.
-*Mainly small dogs, esp. Yorkies
-*Females>males
-===Histology===
-**Arteriolarization of central veins
-**smooth muscle proliferation (segmental) within the walls of central veins
-**random distribution of small calibre vessels
-**endothelial hyperplasia within portal triads
-**dilation of periacinar vascular spaces.
-**May also see decreased diameter of intrahepatic veins.
-*Can’t be accurately distinguished from PSS alone.
-*Seen in older dogs than PSS
-*Higher MCV, serum postprandial bile acid concentrations, serum albumin and cholesterol concentrations when PSS and HMD together, compared to HMD alone.
 == Idiopathic noncirrhotic portal hypertension ==