Changes

Diseases that cause [[Bone Marrow - Anatomy & Physiology|bone marrow]] suppression include:

Diseases that cause [[Bone Marrow - Anatomy & Physiology|bone marrow]] suppression include:

*'''Aplastic anaemia''' caused by ingestion of bracken or administration of oestrogens, [[Chloramphenicol|chloramphenicol]] or [[Sulphonamides|sulphonamide]] antibiotics.  Prolonged use of [[NSAIDs#Phenylbutazone|phenylbutazone]] or salicylates may cause the same disease.

*'''Aplastic anaemia''' which can be caused by the ingestion of bracken or administration of oestrogens, [[Chloramphenicol|chloramphenicol]] or [[Sulphonamides|sulphonamide]] antibiotics.  Prolonged use of [[NSAIDs#Phenylbutazone|phenylbutazone]] or salicylates may cause the same disease.

*'''Infectious diseases''' that reduce stem cell function, including [[Distemper|canine distemper]], [[Canine Parvovirus|canine parvovirus]] and [[Feline Panleucopaenia|feline panleucopaenia virus]].

*'''Infectious diseases''' that reduce stem cell function include [[Distemper|canine distemper]], [[Canine Parvovirus|canine parvovirus]] and [[Feline Panleucopaenia|feline panleucopaenia virus]].

*'''Myelophthisis''', the displacement of the normal cell lines of the bone marrow by another cell or tissue type may also reduce the function of the megakaryocytes. Possible diseases in this category include '''myelofibrosis''' and '''immunoproliferative''' or '''myeloproliferative''' neoplastic disease.

*'''Myelophthisis''' is the displacement of the normal cell lines of the bone marrow by another cell or tissue type which may also reduce the function of the megakaryocytes. Diseases in this category include '''myelofibrosis''' and '''immunoproliferative''' or '''myeloproliferative''' neoplastic disease.

*'''Radiotherapy''' or myelosuppressive '''chemotherapy''' may cause reversible bone marrow suppression.

*'''Radiotherapy''' or myelosuppressive '''chemotherapy''' may cause reversible bone marrow suppression.

Diseases that cause '''increased destruction of platelets'''

Diseases that cause '''increased destruction of platelets'''

*'''[[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]]''' is a common autoimmune disease that leads to the production of antibodies against platelets and their subsequent destruction by cells of the monocyte phagocyte system (MPS).

*'''[[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]]''' is a common autoimmune disease that leads to the production of antibodies against platelets and their subsequent destruction by cells of the [[Monocytes|monocyte]] phagocyte system (MPS).

*'''Infectious diseases''' that cause destruction of platelets include [[Bovine Viral Diarrhoea Virus|bovine viral diarrhoea]] (BVD), [[Classical Swine Fever|classical swine fever]] and [[Infectious Canine Hepatitis|infectious canine hepatitis]].  The parasites ''[[Ehrlichia platys|Anaplasma platys]]'', ''[[Ehrlichia phagocytophila|Anaplasma phagocytophilum]]'' and ''[[Ehrlichia canis]]'' may also cause infectious thrombocytopaenia.  Any severe bacterial infection, including those caused by [[:Category:Staphylococcus species|''Staphylococci'']] and the Gram negative bacteria that produce endotoxin (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas spp.'']] or [[Salmonella|''Salmonella spp.'']]) may also result in the destruction of platelets.

*'''Infectious diseases''' that cause destruction of platelets include [[Bovine Viral Diarrhoea Virus|bovine viral diarrhoea (BVD)]], [[Classical Swine Fever|classical swine fever]] and [[Infectious Canine Hepatitis|infectious canine hepatitis]].  The parasites ''[[Ehrlichia platys|Anaplasma platys]]'', ''[[Ehrlichia phagocytophila|Anaplasma phagocytophilum]]'' and ''[[Ehrlichia canis]]'' may also cause infectious thrombocytopaenia.  Any severe bacterial infection, including those caused by [[:Category:Staphylococcus species|''Staphylococci'']] and the Gram negative bacteria that produce endotoxins (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas spp.'']] or [[Salmonella|''Salmonella spp.'']]) may also result in the destruction of platelets.

Diseases that cause '''sequestration of platelets''' usually involve some enlargement of the spleen, as this is the major organ where platelets are stored outside of the circulation.  Examples include:

Diseases that cause '''sequestration of platelets''' usually involve some enlargement of the spleen, as this is the major organ where platelets are stored outside of the circulation.  A common example would be [[Haemangiosarcoma|haemangiosarcoma]] of the spleen and liver. Splenic enlargement under general anaesthesia maintained with agents such as [[Barbiturates|barbiturates]] and [[Phenothiazines|phenothiazines]] can also lead to sequestration of platelets.

*[[Haemangiosarcoma]] of the spleen and liver

*Splenic enlargement under general anaesthesia maintained with agents such as [[Barbiturates|barbiturates]] and [[Phenothiazines|phenothiazines]]

'''Artefactual'''  or spurious thrombocytopaenia

'''Artefactual'''  or spurious thrombocytopaenia