Gastric Ulceration - Horse
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This article is still under construction. |
| Also known as: | Gastroduodenal ulceration Equine Gastric Ulcer Syndrome |
Description
Prevalence
Racehorses 80-100% Show horses 60% Ponies 78% Endurance 67%
Signalment
Foals and young horses in training
Pathophysiology
NOT associated with Helicobacter pylori and not typically associated with Gasterophilus
Risk Factors
Housing, stress, boredom, training, diet Feeding practices:
- Grain and pelleted feed asssociated with increased serum gastrin (Smyth et al 1988)
- Eating behaviour (grazing vs feeds)
- Feed constituents (alfalfa)
- Individual variability
Exercise and training
- Strenuous exercise stimulates gastrin release which has effects on HCL secretion, gastric emptying, gastric blood flow
Clinical syndrome
Often asymptomatic, may see:
- Poor appetite
- Dullness
- Change in attitude
- Reduced performance
- Reluctance to train
- Poor condition
- Weight loss
- Diarrhoea
- Low-grade colic
- Excessive recumbency
- Bruxism (in foals only)
Diagnosis
Definitive diagnosis requires gastroscopy (cannot do in foals as need to starve prior to exam)
Laboratory tests
No known laboratory markers, attempts to detect occult blood in faeces unreliable in horse
Endoscopy
Minimum endoscope length of two metres and 2.8-3.0 metre instruments are reuired for duodenoscopy Foals - lesions mainly in glandular epithelium Adults - margo plicatus and squamous epithelium
Pathology
Treatment
Proton pump inhibitors: only omeprazole (Gastroguard) is licensed for horses. Given PO once daily (4mg/kg) for 3-4 wks, most effective drug at controlling HCl secretion (decreases basal and stimulated release) Histamine H2 receptor antagonists:
- ranitidine 7mg/kg TID for 3-4wks
- cimetidine 25mg/kg QID for 3-4wks
Gastric protectants: sucralfate 10-20mg/kg TID for 2-4wks Antacids: magnesium and aluminium hydroxides (NOT recommended as have massive rebound effect)
Prognosis
Prevention
Gastroguard at lower dose (1mg/kg) daily for 3-4wks
References
Gastric Ulceration - all species
- Affects the pars oesophagea (margo plicatus) in adults and foals.
- Due to parasites - Gasterophilus (Bots).
- Bots are not as common as they once were.
- Look like big pink maggots.
- Killed by Ivermectin.
- Gasterophilus leave large ulcers in glandular regions of the stomach.
- Ulcers / erosions are quite deep.
- The parasites are believed to be non-pathogenic, but in large numbers they probably produce some discomfort and poor growth.
- Carcinoma can also produce ulceration in the stomach of the horse as, in other species.
- In foals, the glandular area may sometimes be affected.
- This may be e.g. stress-related, or due to used of NSAIDs.