Category:Cell Mediated Autoimmune Diseases

1. Rheumatoid Arthritis

2. Diabetes Mellitus type I

Diabetes Mellitus-Brian Catchpole RVC 2008

Pathogenesis:

• Type IV hypersensitivity
• The CTLs think that all the beta cells in the pancreas are infected by a virus, as it wrongly detects a self antigen presented by the MHC class I on the surface of the cell as foreign.
• Autoreactive CD8+ CTLs are inadvertently activated, destroying the beta cells, thus preventing the secretion of insulin and causing diabetes type 1 (see diagram).

3. Hypothyroidism (lymphocytic throiditis)

Pathogenesis: Type IV hypersensitivity

• T cell mediated

4. Hypoadrenocorticism (Addisons disease)

Pathogenesis: Type IV hypersensitivity