Rheumatoid Arthritis
Revision as of 15:00, 11 August 2010 by Bara (talk | contribs) (Created page with "right|thumb|150px|Rheumatoid Arthritis-Brian Catchpole RVC 2008 '''Pathogenesis:''' * [[Type IV Hypersensitivity - Wi...")
Pathogenesis:
- Type IV hypersensitivity: CD4 Th-1 cell mediated.
- Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction.