Changes

Brucella species (view source)

593 bytes added , 17:10, 17 May 2008

no edit summary

Line 47: Line 47:

*Serological testing of milk (Milk Ring Test) and beef cattle (Rose Bengal Plate Test)

*Serological tests detect anti-lipopolysaccharide antibodies

+

*LPS antigen present in virulent as well as some vaccine strains therefore vaccination may confuse serological testing

+

*False positives due to cross-reaction with LPS in other bacteria

+

*Vaccination:

+

**Strain S19, a live vaccine, stimulating a cell-mediated immune response; vaccination of young animals; interferes with serological testing

+

**Newer RB51 vaccine has no LPS O-antigen therefore not detcted by serological tests

+

**Live attenuated ''Brucella melitensis'' vaccine to protect sheep and goats against ''B. melitensis''

+

*Test and slaughter program has eradicated Brucellosis in the UK

462

edits