Changes

* The CTl killing mechanism is initiated by direct CTL-target cell contact.   

* The CTl killing mechanism is initiated by direct CTL-target cell contact.   

* The cells involved bind by antigen/MHC class I-TcR interaction.

* The cells involved bind by antigen/[[Adaptive Immune System - WikiBlood#Structure and Function of MHC Class I|MHC]]

class I-TcR interaction.

** This results in the CTL's intracellular granules becoming localised to the area of contact.  

** This results in the CTL's intracellular granules becoming localised to the area of contact.  

*** These granules contain most of the molecules responsible for cytotoxicity.  

*** These granules contain most of the molecules responsible for cytotoxicity.  

*** Proteolytic enzymes.

*** Proteolytic enzymes.

*** Target cell nucleases.

*** Target cell nucleases.

*** Cause programmed cell death.  

*** Cause programmed cell death.

==T-Cell Activation==

==T-Cell Activation==