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====Pathogenesis====
 
====Pathogenesis====
*Sporadically induce a fatal over-active T cell division, where virus encodes anti-apoptotic protein in dead-end host
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[[Image:MCF1.gif|right|thumb|125px|<small><center>Sever Oculo-nasal Discharge of MCF (Courtesy of Alun Williams (RVC))</center></small>]]
*'''Latent''' infection
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*Clinical signs in cattle: [[Image:MCF2.gif|right|thumb|125px|<small><center>Fissures on tongue (no vesicles) in MCF (Courtesy of Alun Williams (RVC))</center></small>]]
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**Necrotising lesions in upper respiratory tract and eye: conjunctivitis and corneal oedema / opacity (keratitis or "blue eye" - characteristic feature)
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**Fever and [[Intestine Diarrhoea - Pathology|diarrhoea]] with severe oculo-nasal discharge
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**Not eating, dull with ulcers on muzzle may spread to rest of face with brown exudate
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**Ulcers also on tongue, dental pad, and cheeks that regularly become secondarily infected
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**Lymphocyte proliferation progresses in lymphoid tissue and blood until death
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*Lymph nodes completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]] - similar to [[lymphosarcoma]]; synonym lymphoma. (resembles lymphotropic herpes virus such as [[Epstein Barr]]) 
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*Also vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by [[Lymphocytes - WikiBlood|lymphocytes]].
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*Ulcers are due to hypoxia of epithelium resulting from vascular lesions
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*Sporadically induce a fatal '''over-active T cell division''', where virus encodes anti-apoptotic protein in dead-end host
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*'''Latent''' infection that is invariably fatal
 
*Virus excretion increased during periparturient period
 
*Virus excretion increased during periparturient period
*Clinical signs in cattle:
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**Necrotising lesions in upper respiratory tract, [[Cavity & Gingiva - Pathology#Malignant Catarrhal Fever|gingiva]] and eye
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====Epidemiology====
**Lymphocyte proliferation progresses in lymphoid tissue and blood until death
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*Not all that common in UK
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*Affects whole body but especially evident clinically in face and mouth
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*Sporadic and often seen in animals mixing with sheep (carriers)
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*In parts of Africa see long outbreaks (diff serotypes) carried by Wildebeest 
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*In deer produces very serious outbreaks, probably primarily sheep virus
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*Often youngish animal 6 months to 1 year
    
====Control====
 
====Control====
 
*Wildebeest should not be stocked in zoos where possible
 
*Wildebeest should not be stocked in zoos where possible
 
*Sheep and deer should be housed separately
 
*Sheep and deer should be housed separately
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