Line 30: Line 30:     
==Diagnosis==
 
==Diagnosis==
Differentials (7)
+
Anticoagulant rodenticide toxicosis is usually diagnosed based on history of ingestion of the substance. Differential diagnoses when massive hemorrhage is encountered include disseminated intravascular coagulation, congenital factor deficiencies, von Willebrand’s disease, platelet deficiencies, and canine ehrlichiosis. A prolonged prothrombin, partial thromboplastin, or thrombin time in the presence of normal fibrinogen, fibrin degradation products, and platelet counts is strongly suggestive of anticoagulant rodenticide toxicosis, as is a positive therapeutic response to vitamin K1.
* Other causes of blood loss and anaemia: Trauma and clotting defects such
+
 
as inherited conditions, autoimmune disorders, chronic liver disease and
  −
disseminated intravascular coagulation (DIC).
  −
* Other causes of dyspnoea: Thoracic fluid, heart disease, lung disease and
  −
respiratory obstruction.
  −
* Other causes of acute collapse: Trauma, endotoxaemia and causes of shock
   
===Clinical Signs===
 
===Clinical Signs===
 
The diagnosis of anticoagulant rodenticide toxicosis is
 
The diagnosis of anticoagulant rodenticide toxicosis is
Line 56: Line 51:  
Clinical signs generally reflect some manifestation of hemorrhage, including anemia, hematomas, melena, hemothorax, hyphema, epistaxis, hemoptysis, and hematuria. Signs dependent on hemorrhage, such as weakness, ataxia, colic, and polypnea, may be seen. Depression and anorexia occur in all species even before bleeding occurs.
 
Clinical signs generally reflect some manifestation of hemorrhage, including anemia, hematomas, melena, hemothorax, hyphema, epistaxis, hemoptysis, and hematuria. Signs dependent on hemorrhage, such as weakness, ataxia, colic, and polypnea, may be seen. Depression and anorexia occur in all species even before bleeding occurs.
   −
===Diagnostic Imaging===
+
differentials
 +
Other causes of blood loss and anaemia: Trauma and clotting defects such
 +
as inherited conditions, autoimmune disorders, chronic liver disease and
 +
disseminated intravascular coagulation (DIC).
 +
* Other causes of dyspnoea: Thoracic fluid, heart disease, lung disease and
 +
respiratory obstruction.
 +
* Other causes of acute collapse: Trauma, endotoxaemia and causes of shock
    
===Laboratory Tests===
 
===Laboratory Tests===
6,502

edits