Clostridium piliforme

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  • Spore-forming filamentous Gram negative intracellular pathogen
  • Only grows in tissue culture or embryonated eggs
  • Causes Tyzzer's disease - severe hepatic necrosis
  • Sporadic disease in foals, calves, dogs, cats
  • Foals under 6 weeks, found dead or comatose
  • Incubation period up to 1 week
  • Depression, anorexia, fever, jaundice, diarrhoea
  • Hepatomegaly and necrosis on post mortem
  • Diagnosis: Warthin-Starry silver impregnation technique demonstrates organisms in hepatocytes