Endocrine Pancreas - Pathology
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Pancreas, Endocrine - Degenerative Pathology
Neoplasia
Insulin Secreting Neoplasms
Carcinomas
- Larger than adenomas
- Multilobular
- Invasive into parenchyma and surrounding tissue
- Metastasis into lymph nodes, liver mesentery, omentum
- Few mitotic figures
Gastrinoma
Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine
- Described in dogs, cats
- Known as Zollinger-Ellison syndrome in humans
- Uncommon compared to beta cell neoplasms
- Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration
Clinical signs
Pathology
- Multiple variably sized neoplasms
- Increased connective tissue mass - firm
- Partiallty encapsulated
- Invade locally
- Metastases to liver and local lymph nodes are common
Glucagonoma
- Very rare
- Characterised by
- Hyperglycaemia
- Vacuolar hepatopathy
- Skin erythema with superficial necrotising dermatitis
- Diagnosis in dogs is difficult as presents together with DM