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Line 27: |
| *Lowered level of plasma albumin contributes to the development of ascites | | *Lowered level of plasma albumin contributes to the development of ascites |
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− | ==Syndromes in liver failure== | + | ==Liver Function== |
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− | [[Icterus]]
| + | * PROTEIN METABOLISM |
| + | Protein synthesis, regulation of amino acids Ammonia synthesis and detoxification |
| + | * CARBOHYDRATE METABOLISM |
| + | Blood glucose regulation Maintenance of glycogen reserve Regulation of intermediary carbohydrate metabolism |
| + | * LIPID METABOLISM |
| + | Synthesis of cholesterol, phospholipids and lipoproteins; fatty acid oxidation Bile acid synthesis and regulation |
| + | * BIOTRANSFORMATION AND EXCRETION |
| + | Bilirubin, ammonia, steroid hormones Drugs, copper, cholesterol |
| + | * IMMUNOLOGICAL FUNCTIONS |
| + | Antigen trapping by Kupffer's cells Synthesis of complement, interleukin |
| + | * VITAMIN ACTIVATION, STORAGE AND ELIMINATION |
| + | * STORAGE OF MINERALS (IRON, COPPER, ZINC, MANGANESE) |
| + | * INACTIVATION OF ENDOCRINE HORMONE |
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− | [[Photosensitisation]]
| + | ==Clinical Signs== |
| + | The animal may present with non specific signs such as weight loss, anorexia, vomiting, diarrhoea, lethargy and PU/PD. The may also present with syndromes specifically related to primary or secondary liver disease such as: |
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− | [[Hepatic Encephalopathy]] | + | * [[Icterus]] |
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| + | * [[Photosensitisation]] |
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| + | * [[Hepatic Encephalopathy]] |
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| + | * [[Bleeding Tendencies]] or coagulopathy |
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| + | * [[Hypoalbuminaemia]] and ascites |
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| + | * Hepatomegaly or fibrosis of the liver |
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| + | * Drug intolerance |
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| + | ==Diagnosis== |
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| + | ===Laboratory Tests=== |
| + | * Haematology, biochemistry, urinanalysis |
| + | * Serum bile acid test pre- and post-prandial |
| + | * Coagulation profile |
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− | [[Bleeding Tendencies]]
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− | [[Hypoalbuminaemia]]
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