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SYSTEMIC MYCOSES
WIKIBUGS FLASHCARDS


Adiaspiromycosis

Question Answer Article
What is the pathogenesis of an adiaspiromycosis infection?
  • Non-contageous
  • Pulmonary mycosis
  • Respiratory infection
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Which animals are mostly affected?
  • Rodents
  • Small animals
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Aspergillosis

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Fill in the missing words about aspergillosis infections Aspergiollosis is found worldwide. It is widely present in nature and can colonise a wide range of substrates under different environmental conditions. It is abundant in hay, straw and grain which have heated during storage. Link to Answer Article
What are the clinical signs of infection in birds?
  • Diarrhoea
  • Listlessness
  • Pyrexia
  • Loss of appetite
  • Loss of condition
  • Convulsions
  • Death
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What do aspergillosis lesions look like in cattle?
  • Up to 2mm in diameter
  • Lesions contain asteroid bodies with a germinated spore in the centre
  • Miliary lesions in acute infections
  • Granulomatous and calcified lesions in chronic infections
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What diseases does aspergillosis infections cause in horses?
  • Gutteral pouch mycosis
  • Chronic obstructive pulmonary airway disease (COPD)
  • Mycotic abortion
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What do colonies look like on Sabauraud's Dextrose agar?
  • White colonies initially
  • Colonies turn green and then dark green
  • Flat and velvety
  • Colony colour varies with species
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How would you treat an infection of aspergillosis?
  • Surgery
  • Antifungal drugs
    • Ketoconazole
    • Nystatin
    • Amphotericin B
    • 5-fluorocytosine
    • Thiabendazole
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Blastomycosis

Question Answer Article
Describe the pathogenesis of a blastomycosis infection?
  • Respiratory infection
  • Lesions start in the lungs
  • Haematogenous dissemination
  • Can be found in lesions in the eyes, brain, bones, skin and genitalia
  • Fatal if not treated
  • Skin lesions may ulcerate forming granulomatous nodules
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What do colonies look like on Blood agar?
  • Cream coloured
  • Waxy
  • Crinkled
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What do colonies look like on Sabauraud's Dextrose agar?
  • Grey coloured
  • Moist
  • White cotton-like mycelium which turns tan, brown and then black
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How would you diagnose an infection?
  • Clinical signs
  • Complement fixation test
  • ELISA
  • Counterimmunoelectrophoresis
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How would you treat an infection?
  • Amphotericin B
  • Imidazoles
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Coccidioidomycosis

Question Answer Article
What environmental conditions does Coccidioides immitis prefer?
  • Arid
  • Dusty
  • E.g. Mexico and the South-Western USA
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Describe the pathogenesis of coccidiomycosis infections?
  • Respiratory infection
  • Causes localised nodules and granulomas
  • Lesions usually seen in the mediastinal lymph nodes and lungs
  • Dissemination can occur to the lungs, liver, spleen, brain and bones
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How would you diagnose an infection?
  • Clinical signs
  • Complement fixation test
  • Latex agglutination
  • Immunodiffusion
  • A positive skin test indicates exposure
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Entomophthoromycisus

Question Answer Article
What clinical signs present with an infection of entomophthoromycisus?
  • Ulcerative granulomas in subcutaneous tissue
  • Large lesions affecting the skin on the head, neck and chest which have fistulous tracts extending to the lymph nodes
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How would you treat an infection?
  • Surgical excision
  • Amphotericin B
  • Ketoconazole
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Histoplasmosis

Question Answer Article
True or False: Histoplasmosis infections occur solely through ingestion of fungal spores
  • False
  • Infection is through both ingestion and respiratory
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Which organs/bodily systems are affected?
  • Reticuloendothelial
  • Pulmonary
  • Intestinal
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Histoplasma capsulatum are found intracellularly in which type of cell?
  • Macrophages
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How would you diagnose an infection?
  • Clinical signs
  • Complement fixation test
  • Counterimmunoelectrodiffusion
  • Immunodiffusion
  • A positive skin test indicates exposure only (not an active infection)
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How would you treat an infection?
  • Amphotericin B
  • If Amphotericin B is contra-indicated, imidazoles can be given
  • In acute and disseminated cases, the prognosis is poor
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Zygomycosis

Question Answer Article
Which fungi cause zygomycosis?
  • Mucor
  • Absidia
  • Rhizopus
  • Mortierella
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Describe the general pathogenesis of zygomycosis infections?
  • Infection is through inhalation and ingestion
  • Lymph nodes of the repiratory and ailimentary tract are infected
  • Lymph nodes enlarge and become caseous
  • Causes stomach and intestinal ulcers
  • Lesions are usually localised (can become generalised)
  • Granulomatous lesions can ulcerate
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Where do lesions occur in pigs?
  • Mediastinal and submandibular lymph nodes
  • Stomach ulcers
  • Embolic tumours in the lungs and liver
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Where do lesions occur in cattle?
  • Mediastinal, bronchial and mesenteric lymph nodes
  • Ulcers in the nasal cavity and abomasum
  • Can contaminate the placenta
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True or False: Zygomycosis are common labaratory contaminants
  • True
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How would you treat an infection
  • Amphotericin B
  • Surgical excision
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