Leptospira is from the family,Leptospiraceae which is a spirochaetes species. Leptospira is a motile, helical bacteria found in aquatic environments. It causes Leptospirosis in all animals, which can range from mild urogenital tract infections to systemic diseases. The organisms persist in the kidney tubules or genital tracts of carrier animals and are shed in urine. Transmission occurs via direct contact. Maintenance hosts may transmit the infection to incidental hosts, which are less susceptible to infection, but develop serious disease. Leptospira may cause severe systemic disease, resulting in enteritis.
The pathogenesis of Leptospira depends on virulence of the bacteria and susceptibility of the host. Leptospires invade tissues through moist skin or via mucous membranes, aided by their motility. They may invade via receptor-mediated endocytosis and then pass through the body via the blood stream. Antibodies clear the organisms from the blood stream after about 10 days of infection.
The organisms may persist in the renal tubules, uterus, eye or meninges. They evade phagocytosis possibly via macrophage apoptosis and damage red blood cell membranes and endothelial and liver cells, leading to haemolytic anaemia, jaundice, haemoglobin pigmentation, haemoglobinuria and haemorrhage in acute leptospirosis.
Leptospira can be diagnosed by clinical signs and history of exposure. Dark-field microscopy of urine may detect organisms as may isolation from blood or urine by culture or animal inoculation. The fluorescent antibody technique can be used for identification in tissues. Silver impregnation, molecular techniques such as PCR and Serology using microscopic agglutination test or ELISA can also be used.
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|Laboratory techniques in diagnosis of leptospirosis. Venkatesha, M. D.; Intas Pharmaceuticals Ltd, Ahmedabad, India, Intas Polivet, 2006, 7, 2, pp 332-336, 20 ref.|
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