Changes

<br />

<br />

<br />

<br />

Neutrophils also produce vasoactive peptides, for example, histamine and bradykinin which, as their name suggests, activate the endothelium to become more "leaky" causing a great increase in extravasation of blood granulocytes and [[Monocytes|monocytes]], and the diffusion of plasma proteins to the site of infection. These peptides, released from other cells as well as neutrophils, are responsible for the classical signs of [[Inflammation - Introduction|inflammation]]: redness ('''rubor'''), heat ('''calor'''), swelling ('''tumour'''), and pain ('''dolor'''), often accompanied by loss of function. Neutrophil activation in an inflammatory lesion also results in the release of '''prostaglandins''' which are responsible for vasoactive changes and for pain (N.B. These are reduced with cyclo-oxygenase (COX) inhibition for example with the NSAID (non-steriodal anti-inflammatory drugs)'s Aspirin and Ibuprofen).

Neutrophils also produce vasoactive peptides, for example, histamine and bradykinin which, as their name suggests, activate the endothelium to become more "leaky" causing a great increase in extravasation of blood granulocytes and [[Monocytes|monocytes]], and the diffusion of plasma proteins to the site of infection. These peptides, released from other cells as well as neutrophils, are responsible for the classical signs of [[Inflammation - Introduction|inflammation]]: redness ('''rubor'''), heat ('''calor'''), swelling ('''tumour'''), and pain ('''dolor'''), often accompanied by loss of function. Neutrophil activation in an inflammatory lesion also results in the release of '''prostaglandins''' which are responsible for vasoactive changes and for pain (N.B. These are reduced with cyclo-oxygenase (COX) inhibition for example with the [[NSAIDs|NSAIDs]] (non-steriodal anti-inflammatory drugs) aspirin and ibuprofen).

<br />

<br />

<br />

<br />

It is for the reasons above that neutrophils have been described as the archetypal cell associated with [[:Category:Inflammation|acute inflammation]].

It is for the reasons above that neutrophils have been described as the archetypal cell associated with [[Acute Inflammation - Introduction|acute inflammation]].

<br />

<br />

<br />

<br />

<br />

<br />

<br />

<br />

Their removal from the site after the removal of infection is an important step in the resolution of the lesion. Under physiological conditions the neutrophils undergo a process called '''apoptosis''' (or ''Programmed Cell Death''), and are then cleared by tissue macrophages (see above). However, if there are too few macrophages to clear the cells, or the infection is resulting in the death of the neutrophils, they undergo a process called '''necrosis'''. When these neutrophils that have undergone necrosis accumulate at the site of infection it forms '''pus'''.

Their removal from the site after the removal of infection is an important step in the resolution of the lesion. Under physiological conditions the neutrophils undergo a process called '''apoptosis''' (or ''Programmed Cell Death''), and are then cleared by tissue macrophages ([[#Macrophages|see above]]). However, if there are too few macrophages to clear the cells, or the infection is resulting in the death of the neutrophils, they undergo a process called '''necrosis'''. When these neutrophils that have undergone necrosis accumulate at the site of infection it forms '''pus'''.

==[[Eosinophils|Eosinophils]]==

==[[Eosinophils|Eosinophils]]==