Changes

**Stain with Giemsa or Wright and examine under oil immersion lens

**Stain with Giemsa or Wright and examine under oil immersion lens

*Present intracellularly in macrophages as oval yeast cells with few buds

*Present intracellularly in [[Macrophages - WikiBlood|macrophages]] as oval yeast cells with few buds

**Clear halo is seen around the darker staining central material

**Clear halo is seen around the darker staining central material

*Grows on Sabouraud's Dextrose agar

*Grows on Sabouraud's Dextrose agar

**Creamy white turning tan and then brown

**Creamy white colonies, turning tan coloured and then brown

*Also grows on Blood agar

*Also grows on Blood agar

**If [[Antifungal Drugs#Polyene Antifungals|Amphotericin B]] is contra-indicated, [[Antifungal Drugs#Imidazoles|imidazoles]] can be given orally

**If [[Antifungal Drugs#Polyene Antifungals|Amphotericin B]] is contra-indicated, [[Antifungal Drugs#Imidazoles|imidazoles]] can be given orally

*THe prognosis is poor in acute and disseminated cases

*The prognosis is poor in acute and disseminated cases

==Zygomycosis==

==Zygomycosis==