Changes

Platelet factors catalyse the conversion of soluble fibrinogen to insoluble fibrin resulting in a  progessive infiltration of the initial thrombocyte plug by strands of fibrin, leading to the formation of a composite plug. The fibrin also polymerises, causing coagulation of the blood and clot formation.

Platelet factors catalyse the conversion of soluble fibrinogen to insoluble fibrin resulting in a  progessive infiltration of the initial thrombocyte plug by strands of fibrin, leading to the formation of a composite plug. The fibrin also polymerises, causing coagulation of the blood and clot formation.

After the clot has formed, the platelets actively contract; the contractile protein is thrombosthenin. The fibrin strands shorten, increasing the strength of the clot and bringing the blood vessel walls closer together. The clot is progressively broken down by [[Haemostasis - Pathology#Fibrinolysis|fibrinolysis]] and infiltration by new fibroblasts and capillaries occurs.

After the clot has formed, the platelets actively contract; the contractile protein is thrombosthenin. The fibrin strands shorten, increasing the strength of the clot and bringing the blood vessel walls closer together. The clot is progressively broken down by fibrinolysis and infiltration by new fibroblasts and capillaries occurs.

[[Granulation Tissue|Granulation tissue]] is formed within 3 days, and permanent repair, either functional or non-functional, occurs in around 1 week.

[[Granulation Tissue|Granulation tissue]] is formed within 3 days, and permanent repair, either functional or non-functional, occurs in around 1 week.