Difference between revisions of "Immunoglobulin E"
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==Overview== | ==Overview== | ||
[[Image:LH IgE.png|thumb|250px|right|'''IgE''']] | [[Image:LH IgE.png|thumb|250px|right|'''IgE''']] | ||
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Commonly referred to as ''IgE''. | Commonly referred to as ''IgE''. | ||
| − | Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors | + | Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors before it can bind to the target, and is found in low levels in blood plasma. Like [[IgA]], it is produced by [[B cell differentiation|plasma cells]] and is mainly localised to mucosal surfaces. |
==Structure== | ==Structure== | ||
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==Function== | ==Function== | ||
| − | IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation | + | IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation. It is involved in [[Type I Hypersensitivity|type I hypersensitivity reactions]]. Cross-linking of IgE molecules by antigens, triggers [[Mast Cells|mast cell]] degranulation and an inflammatory response. IgE has considerable involvement in producing immunity to parasitic worms, particularly [[:Category:Nematodes|nematode]] parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic [[Eosinophils|eosinophils]], [[Macrophages|macrophages]], and so on. |
==References== | ==References== | ||
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<br><br> | <br><br> | ||
{{Jim Bee 2007}} | {{Jim Bee 2007}} | ||
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[[Category:Immunoglobulins]] | [[Category:Immunoglobulins]] | ||
[[Category:A&P Done]] | [[Category:A&P Done]] | ||
Revision as of 09:41, 25 May 2012
Overview
Commonly referred to as IgE.
Unlike IgM, IgG and IgA, IgE does not function as a soluble antibody, with binding to Fcε receptors before it can bind to the target, and is found in low levels in blood plasma. Like IgA, it is produced by plasma cells and is mainly localised to mucosal surfaces.
Structure
IgE is Y-shaped with heavy chain type ε, and exists as a monomer.
Note: Janeway [1] states that IgE has no hinge region whereas Tizard [2] indicates that it does.
Production
It is produced when TH2 cells stimulate CD40 and produce IL-4 and IL-13, which causes B cell differentiation to plasma cells and class switching to IgE production.
Function
IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation. It is involved in type I hypersensitivity reactions. Cross-linking of IgE molecules by antigens, triggers mast cell degranulation and an inflammatory response. IgE has considerable involvement in producing immunity to parasitic worms, particularly nematode parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on.
References
Links
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Originally funded by the RVC Jim Bee Award 2007 |