Changes

==Overview==

==Overview==

[[Image:LH IgE.png|thumb|250px|right|'''IgE''']]

[[Image:LH IgE.png|thumb|250px|right|'''IgE''']]

Commonly referred to as ''IgE''.

Commonly referred to as ''IgE''.

Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody and is found in low levels in blood plasma. Like [[IgA]], it is produced by plasma cells and is mainly localised to mucosal surfaces.

Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors required before it can bind to the target antigen, and is found in low levels in blood plasma. Like [[IgA]], it is produced by [[B cell differentiation|plasma cells]] and is mainly localised to mucosal surfaces.

==Structure==

==Structure==

==Production==

==Production==

It is produced when Th2 cells stimulate CD40 and produce Il-4 and Il-13, which causes B cell differentiation to plasma cells and class switching to IgE production.

It is produced when T_H2 cells stimulate CD40 and produce IL-4 and IL-13, which causes B cell differentiation to plasma cells and class switching to IgE production.

==Function==

==Function==

IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation. It is involved in [[Type I Hypersensitivity|type I hypersensitivity reactions]]. Cross-linking of IgE molecules by antigens, triggers [[Mast Cells|mast cell]] degranulation and an inflammatory response. IgE has considerable involvement in producing immunity to parasitic worms, particularly [[:Category:Nematodes|nematode]] parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic [[Eosinophils|eosinophils]], [[Macrophages|macrophages]], and so on.

IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation when bound to target. It is involved in [[Type I Hypersensitivity|type I hypersensitivity reactions]]. Cross-linking of IgE molecules by antigens, triggers [[Mast Cells|mast cell]] and [[Eosinophil|eosinophil]] degranulation and an inflammatory response. IgE has considerable involvement in producing [[Immunity to Parasites|immunity to parasitic worms]], particularly [[:Category:Nematodes|nematode]] parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic [[Eosinophils|eosinophils]], [[Macrophages|macrophages]], and so on.

==References==

==References==

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{{Jim Bee 2007}}

{{Jim Bee 2007}}

[[Category:Immunoglobulins]]

[[Category:Immunoglobulins]]

[[Category:A&P Done]]

[[Category:A&P Done]]