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==Introduction==

==Introduction==

Mesothelial cells are a specialised type of '''epithelium''' which make up the '''mesothelium''' which lines all serosal surfaces.

Mesothelial cells are a specialised type of '''epithelium''' which make up the '''mesothelium''' which lines all serosal surfaces.

'''Cytologically''', these cells have typical morphological features of round, mononuclear to binuclear cells present individually or in small cohesive clusters.

'''Cytologically''', these cells have typical morphological features of round, mononuclear to binuclear cells present individually or in small cohesive clusters.

Marked mesothelial cellular hyperplasia may have marked cellular pleomorphism and multiple '''strong nuclear criteria for malignancy'''.

Marked mesothelial cellular hyperplasia may have marked cellular pleomorphism and multiple '''strong nuclear criteria for malignancy'''. It may be '''impossible to distinguish''' reactive mesothelial cells from a neoplastic process. This is why the mesothelial cell population should always be '''considered in relation''' to the other types of cell in the sample. If the process is predominantly inflammatory, criteria for malignancy may be tolerated. However if the inflammation is minor and there are many mesothelial cells, one should strongly consider a malignant process.

 

It may be '''impossible to distinguish''' reactive mesothelial cells from a neoplastic process.

 

This is why the mesothelial cell population should always be '''considered in relation''' to the other types of cell in the sample.

 

If the process is predominantly inflammatory, criteria for malignancy may be tolerated. However if the inflammation is minor and there are many mesothelial cells, one should strongly consider a malignant process.

'''Ancillary diagnostics''' such as imaging and biopsy of the lesion should always be considered.

'''Ancillary diagnostics''' such as imaging and biopsy of the lesion should always be considered.

Slatter, D. (2002) '''Textbook of small animal surgery''' ''Elsevier Health Sciences''

Slatter, D. (2002) '''Textbook of small animal surgery''' ''Elsevier Health Sciences''

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[[Category:Alimentary System - Anatomy & Physiology]]

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