Difference between revisions of "Viral skin infections - Pathology"

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===[[Poxviruses]]===
 
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*Lesion development:
 
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**Due to viral invasion of epithelium
 
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**Vascular injury -> ischaemic necrosis
 
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**Stimulation of host DNA -> hyperplastic nodules
 
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*Cutaneous lesions:
 
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**[[Skin Glossary - Pathology|Macule]] -> [[Skin Glossary - Pathology|papule]] -> [[Skin Glossary - Pathology|vesicle]] -> umbilicated [[Skin Glossary - Pathology|pustule]] -> [[Skin Glossary - Pathology|crust]] -> [[Skin Glossary - Pathology|scar]]
 
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====Contagious ecthyma====
 
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[[Image: Contagious ecthyma.jpg|100px|thumb|right|<small><center>Contagious ecthyma (Courtesy of Bristol BioMed Image Archive)</center></small>]]
 
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*Also called '''contagious pustular dermatitis, orf, sore mouth'''
 
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*Caused by a [[Poxviruses#Contagious ecthyma|parapox virus]]
 
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*Affects mainly young sheep, less commonly cattle, humans, dogs
 
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*Starts in abrasions around mouth commisures and spreads to [[Lips - Anatomy & Physiology|lips]], oral mucosa, eyelids and feet
 
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*May also transfer to teats of the mother of an affected lamb
 
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*Lesions typical of poxvirus but very brief vesicle stage
 
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*Most obvious is the proliferative pustular stage
 
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===[[Herpesviridae|Herpesviruses]]===
 
===[[Herpesviridae|Herpesviruses]]===
  
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**Intracellular inclusion bodies may be found at edges of ulcers
 
**Intracellular inclusion bodies may be found at edges of ulcers
 
**Rapid necrosis
 
**Rapid necrosis
 +
 +
===[[Poxviruses]]===
 +
 +
*Lesion development:
 +
**Due to viral invasion of epithelium
 +
**Vascular injury -> ischaemic necrosis
 +
**Stimulation of host DNA -> hyperplastic nodules
 +
*Cutaneous lesions:
 +
**[[Skin Glossary - Pathology|Macule]] -> [[Skin Glossary - Pathology|papule]] -> [[Skin Glossary - Pathology|vesicle]] -> umbilicated [[Skin Glossary - Pathology|pustule]] -> [[Skin Glossary - Pathology|crust]] -> [[Skin Glossary - Pathology|scar]]
 +
 +
====Contagious ecthyma====
 +
[[Image: Contagious ecthyma.jpg|100px|thumb|right|<small><center>Contagious ecthyma (Courtesy of Bristol BioMed Image Archive)</center></small>]]
 +
 +
*Also called '''contagious pustular dermatitis, orf, sore mouth'''
 +
*Caused by a [[Poxviruses#Contagious ecthyma|parapox virus]]
 +
*Affects mainly young sheep, less commonly cattle, humans, dogs
 +
*Starts in abrasions around mouth commisures and spreads to [[Lips - Anatomy & Physiology|lips]], oral mucosa, eyelids and feet
 +
*May also transfer to teats of the mother of an affected lamb
 +
*Lesions typical of poxvirus but very brief vesicle stage
 +
*Most obvious is the proliferative pustular stage
 +
 +
 
===Other viruses===
 
===Other viruses===
 
*Cutaneous lesion are seen with:
 
*Cutaneous lesion are seen with:

Revision as of 10:33, 11 October 2008

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()Map INTEGUMENTARY SYSTEM (Map)
SKIN INFECTIOUS



Herpesviruses

  • Cutaneous lesions may develop with nondermatotropic viruses:
  • Dermatotropic viruses:
    • Bovine herpes virus - 2 = Bovine herpes mammillitis virus
      • May cause generalised disease - pseudolumpy skin
      • Localised disease - bovine herpes mammillitis
        • Mostly in lactating cows
        • Skin trauma is essential for virus invasion
        • Decreased milk production and secondary bacterial mastitis
        • Lesion occur on teats, udder, sometimes perineum, on muzzle of suckling calves
    • Bovine herpes virus - 4 = Bovine herpes mammary pustular dermatitis
      • Similar to localised BHV-2 but milder disease


  • May be latent and reappear at times of stress
  • Grossly:
  • Microscopically:
    • Intraepidermal vesicle
    • Epidermal cell degeneration
    • Acantholysis
    • Syncytial cells may form
    • Intracellular inclusion bodies may be found at edges of ulcers
    • Rapid necrosis

Poxviruses

  • Lesion development:
    • Due to viral invasion of epithelium
    • Vascular injury -> ischaemic necrosis
    • Stimulation of host DNA -> hyperplastic nodules
  • Cutaneous lesions:

Contagious ecthyma

Contagious ecthyma (Courtesy of Bristol BioMed Image Archive)
  • Also called contagious pustular dermatitis, orf, sore mouth
  • Caused by a parapox virus
  • Affects mainly young sheep, less commonly cattle, humans, dogs
  • Starts in abrasions around mouth commisures and spreads to lips, oral mucosa, eyelids and feet
  • May also transfer to teats of the mother of an affected lamb
  • Lesions typical of poxvirus but very brief vesicle stage
  • Most obvious is the proliferative pustular stage


Other viruses

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