Difference between revisions of "Inclusion Body Disease"
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| − | [[Image:Boid_inclusion_body_dis._rbc_inclusions.jpg|200px|thumb|right|'''Inclusion bodies''' | + | [[Image:Boid_inclusion_body_dis._rbc_inclusions.jpg|200px|thumb|right|'''Inclusion bodies''' ©RVC and its licensors, Peer Zwart and Fredric Frye. All rights reserved]] |
==Species predisposition== | ==Species predisposition== | ||
| − | Inclusion body disease is seen in [[Boidae]]. | + | [[Image:CNS_IBD.jpg|200px|thumb|right|'''CNS derangement in [[Burmese Python|Burmese python]]''' ©RVC and its licensors, Peer Zwart and Fredric Frye. All rights reserved]] |
| − | + | Inclusion body disease is seen in [[Boidae]]. Previously the most commonly affected species was [[Burmese Python|Burmese pythons]] but the disease is now most often seen in [[Boa constrictor|boa constrictors]]. It appears to be relatively uncommon in [[Royal Python|royal pythons]] and has not been reported in rosy boas. The occurrence of the disease in non-boids cannot be ruled out since typical signs and lesions have been reported in a [[Kingsnake|kingsnake]]. IBD is primarily seen in adult snakes, however all age groups should be considered susceptible. | |
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| + | Inclusion body disease (IBD) is a worldwide disease of [[Boidae]] and is named for the characteristic intracytoplasmic inclusions seen in the cells of affected snakes. The causative agent of has not been identified although a Retroviridae-like virus has been incriminated. | ||
==Examination== | ==Examination== | ||
| − | + | Classically pythons developed acute CNS signs and boas presented with regurgitation. In fact clinical signs are very variable and may related to secondary bacterial infections in immunosuppressed boids. Common clinical signs include lethargy, anorexia, weight loss or lack of weight gain, pale oral mucous membranes, CNS problems (incoordination, disorientation, slow to loss of righting reflexes, head tremors, opisthotonous, paresis to paralysis), regurgitation (partially digested possibly mucous-covered food food about one week post-prandial), stomatitis, diarrhoea, pneumonia, dermatitis and neoplasia. | |
| − | Classically | ||
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| − | Common clinical signs include | ||
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| + | *See [Snake Physical Examination|snake physical examination]]. | ||
==Diagnosis== | ==Diagnosis== | ||
| − | [[Image:BOID_INCLUS._BODY_DIS._GASTRIC_MUCOSAL_INCLUSIONS.jpg|200px|thumb|right|'''Gastric mucosal inclusions''' | + | [[Image:BOID_INCLUS._BODY_DIS._GASTRIC_MUCOSAL_INCLUSIONS.jpg|200px|thumb|right|'''Gastric mucosal inclusions''' ©RVC and its licensors, Peer Zwart and Fredric Frye. All rights reserved]] |
Since IBD presents with a variety of signs, any sick boid without an obvious aetiology should be suspected of IBD. Especially consider those with regurgitation, CNS signs and bacterial infections. A thorough [[Snake Physical Examination|physical examination]] may rule our other causes. Currently there is no serologic assay available for determining exposure. Diagnostic aids include the following: | Since IBD presents with a variety of signs, any sick boid without an obvious aetiology should be suspected of IBD. Especially consider those with regurgitation, CNS signs and bacterial infections. A thorough [[Snake Physical Examination|physical examination]] may rule our other causes. Currently there is no serologic assay available for determining exposure. Diagnostic aids include the following: | ||
===Blood=== | ===Blood=== | ||
| − | Blood | + | Blood examination may be helpful. [[Lizard and Snake Haematology|Haematology]] may show a leukocytosis with a lymphocytosis. The white blood cell count is variable, ranging from normal (immune system depression) to as high as 100,000. The leucocytes may show toxic changes. Smears are observed for the presence of inclusion bodies. Typically 1% of cells have the inclusion bodies so it is worthwhile doing a buffy coat smear. Biochemistry may show changes in liver parameters. |
| − | [[Image:0087-D_SnN-011-D.jpg|200px|thumb|right|'''Note thick mucus filling the lung''' | + | [[Image:0087-D_SnN-011-D.jpg|200px|thumb|right|'''Note thick mucus filling the lung''' ©Dr. Oscar Razioli]] |
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===Biopsy and histology=== | ===Biopsy and histology=== | ||
Tissues for biopsy include oesophageal tonsils, liver, kidney and gastric mucosa. The presence of cytoplasmic inclusion bodies on histology is diagnostic for IBD. Sometimes very few inclusions are seen so absence of inclusions does not rule out the disease. For antemortem diagnosis biopsies may have be repeated several times to find inclusions. Characteristic histopathology may be seen in several tissues. | Tissues for biopsy include oesophageal tonsils, liver, kidney and gastric mucosa. The presence of cytoplasmic inclusion bodies on histology is diagnostic for IBD. Sometimes very few inclusions are seen so absence of inclusions does not rule out the disease. For antemortem diagnosis biopsies may have be repeated several times to find inclusions. Characteristic histopathology may be seen in several tissues. | ||
| − | * | + | *Find out more in [[Lizard and Snake Specimen Collection and Evaluation|specimen collection and evaluation]]. |
===Necropsy=== | ===Necropsy=== | ||
[[Snake Necropsy|Necropsy]] shows changes associated with secondary bacterial infections. On histology, multiple tissues have been reported to contain cells with inclusions. | [[Snake Necropsy|Necropsy]] shows changes associated with secondary bacterial infections. On histology, multiple tissues have been reported to contain cells with inclusions. | ||
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==Therapy== | ==Therapy== | ||
| − | There is no known treatment. | + | There is no known treatment. [[Lizard and Snake Euthanasia|Euthanasia]] is recommended. |
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==Prevention== | ==Prevention== | ||
| − | A sound preventive medicine programme is the protection. All new snakes should be quarantined for a minimum of 90 days before introduction to others. For larger collections a [[Lizard and Snake Quarantine|quarantine]] of 6 months may be more appropriate. The exact route of transmission is unknown so [[Lizard and Snake Day to Day Practice|hygiene]] and [[Snake Mites|mite]] control are essential. Finally all infected snakes should be [[Lizard and Snake Euthanasia|euthanased]]. | + | A sound preventive medicine programme is the protection. All new snakes should be [[Lizard and Snake Quarantine|quarantined]] for a minimum of 90 days before introduction to others. For larger collections a [[Lizard and Snake Quarantine|quarantine]] of 6 months may be more appropriate. The exact route of transmission is unknown so [[Lizard and Snake Day to Day Practice|hygiene]] and [[Snake Mites|mite]] control are essential. Finally all infected snakes should be [[Lizard and Snake Euthanasia|euthanased]]. |
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[[Category:Snake Viral Diseases]] | [[Category:Snake Viral Diseases]] | ||
Revision as of 12:04, 27 April 2010
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This article is still under construction. |
Species predisposition
Inclusion body disease is seen in Boidae. Previously the most commonly affected species was Burmese pythons but the disease is now most often seen in boa constrictors. It appears to be relatively uncommon in royal pythons and has not been reported in rosy boas. The occurrence of the disease in non-boids cannot be ruled out since typical signs and lesions have been reported in a kingsnake. IBD is primarily seen in adult snakes, however all age groups should be considered susceptible.
Inclusion body disease (IBD) is a worldwide disease of Boidae and is named for the characteristic intracytoplasmic inclusions seen in the cells of affected snakes. The causative agent of has not been identified although a Retroviridae-like virus has been incriminated.
Examination
Classically pythons developed acute CNS signs and boas presented with regurgitation. In fact clinical signs are very variable and may related to secondary bacterial infections in immunosuppressed boids. Common clinical signs include lethargy, anorexia, weight loss or lack of weight gain, pale oral mucous membranes, CNS problems (incoordination, disorientation, slow to loss of righting reflexes, head tremors, opisthotonous, paresis to paralysis), regurgitation (partially digested possibly mucous-covered food food about one week post-prandial), stomatitis, diarrhoea, pneumonia, dermatitis and neoplasia.
- See [Snake Physical Examination|snake physical examination]].
Diagnosis
Since IBD presents with a variety of signs, any sick boid without an obvious aetiology should be suspected of IBD. Especially consider those with regurgitation, CNS signs and bacterial infections. A thorough physical examination may rule our other causes. Currently there is no serologic assay available for determining exposure. Diagnostic aids include the following:
Blood
Blood examination may be helpful. Haematology may show a leukocytosis with a lymphocytosis. The white blood cell count is variable, ranging from normal (immune system depression) to as high as 100,000. The leucocytes may show toxic changes. Smears are observed for the presence of inclusion bodies. Typically 1% of cells have the inclusion bodies so it is worthwhile doing a buffy coat smear. Biochemistry may show changes in liver parameters.
Biopsy and histology
Tissues for biopsy include oesophageal tonsils, liver, kidney and gastric mucosa. The presence of cytoplasmic inclusion bodies on histology is diagnostic for IBD. Sometimes very few inclusions are seen so absence of inclusions does not rule out the disease. For antemortem diagnosis biopsies may have be repeated several times to find inclusions. Characteristic histopathology may be seen in several tissues.
- Find out more in specimen collection and evaluation.
Necropsy
Necropsy shows changes associated with secondary bacterial infections. On histology, multiple tissues have been reported to contain cells with inclusions.
Therapy
There is no known treatment. Euthanasia is recommended.
Prevention
A sound preventive medicine programme is the protection. All new snakes should be quarantined for a minimum of 90 days before introduction to others. For larger collections a quarantine of 6 months may be more appropriate. The exact route of transmission is unknown so hygiene and mite control are essential. Finally all infected snakes should be euthanased.