Difference between revisions of "Endocrine Pancreas - Pathology"
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==Neoplasia== | ==Neoplasia== | ||
[[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] | [[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]] | ||
− | ===Insulin | + | ===[[Insulin Secreting Neoplasms]]=== |
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===Adenomas (insulinomas)=== | ===Adenomas (insulinomas)=== | ||
*Usually single, or less often multiple, small (1-3cm) spherical nodule, yellow to dark red, in one or more lobes | *Usually single, or less often multiple, small (1-3cm) spherical nodule, yellow to dark red, in one or more lobes |
Revision as of 13:36, 9 June 2010
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Pancreas, Endocrine - Degenerative Pathology
Neoplasia
Insulin Secreting Neoplasms
Adenomas (insulinomas)
- Usually single, or less often multiple, small (1-3cm) spherical nodule, yellow to dark red, in one or more lobes
- Thin layer of fibrous tissue separates normal parenchyma
- Small islets of acinar tissue are sometimes present within the neoplasm
- Well differentiated cells
Carcinomas
- Larger than adenomas
- Multilobular
- Invasive into parenchyma and surrounding tissue
- Metastasis into lymph nodes, liver mesentery, omentum
- Few mitotic figures
Gastrinoma
Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine
- Described in dogs, cats
- Known as Zollinger-Ellison syndrome in humans
- Uncommon compared to beta cell neoplasms
- Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration
Clinical signs
Pathology
- Multiple variably sized neoplasms
- Increased connective tissue mass - firm
- Partiallty encapsulated
- Invade locally
- Metastases to liver and local lymph nodes are common
Glucagonoma
- Very rare
- Characterised by
- Hyperglycaemia
- Vacuolar hepatopathy
- Skin erythema with superficial necrotising dermatitis
- Diagnosis in dogs is difficult as presents together with DM