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*General:
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**''Clostridium perfringens'' types B, C and D
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**Found in soil, feaces and intestinal tract
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**Survive in soil as spores
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**Husbandry, changes in diet and environment predispose to proliferation in the intestine
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**Abrupt changes to rich diets and intestinal hypomotility due to overeating
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*Pathogenesis and pathogenicity:
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**Clostridial replication and overgrowth in the interstinal tract of sheep
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**Production of potent exotoxins which cause local and systemic effects of enterotoxaemia
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**Type of toxins produced determine clinical syndrome
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**Haemolysins, collagenases and hyaluronidases also produced
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<big>'''''<ncl style=bullet maxdepth=4 headings=bullet headstart=2 showcats=1 showarts=1>Category:{{PAGENAME}}</ncl></big>
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===Treatment and control of enterotoxaemic infections===
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*Hyperimmune serum
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*Vaccination - vaccinate ewes with toxoid 6 weeks before lambing to allow passive protection of lambs
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*Vaccination of lambs with toxoid before 2 months of age to protect against pulpy kidney
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*Avoid sudden dietary changes
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[[Category:Clostridium_species]]
 
[[Category:Clostridium_species]]
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[[Category:To_Do_-_Bacteria]]
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