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| | + | *General: |
| | + | **''Clostridium perfringens'' types B, C and D |
| | + | **Found in soil, feaces and intestinal tract |
| | + | **Survive in soil as spores |
| | + | **Husbandry, changes in diet and environment predispose to proliferation in the intestine |
| | + | **Abrupt changes to rich diets and intestinal hypomotility due to overeating |
| | + | *Pathogenesis and pathogenicity: |
| | + | **Clostridial replication and overgrowth in the interstinal tract of sheep |
| | + | **Production of potent exotoxins which cause local and systemic effects of enterotoxaemia |
| | + | **Type of toxins produced determine clinical syndrome |
| | + | **Haemolysins, collagenases and hyaluronidases also produced |
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| | + | <big>'''''<ncl style=bullet maxdepth=4 headings=bullet headstart=2 showcats=1 showarts=1>Category:{{PAGENAME}}</ncl></big> |
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| | + | ===Treatment and control of enterotoxaemic infections=== |
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| | + | *Hyperimmune serum |
| | + | *Vaccination - vaccinate ewes with toxoid 6 weeks before lambing to allow passive protection of lambs |
| | + | *Vaccination of lambs with toxoid before 2 months of age to protect against pulpy kidney |
| | + | *Avoid sudden dietary changes |
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| | [[Category:Clostridium_species]] | | [[Category:Clostridium_species]] |
| | + | [[Category:To_Do_-_Bacteria]] |