Difference between revisions of "Erysipelas - Pig"

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Also known as: '''''Diamond Skin Disease'''''
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{{unfinshed}}
  
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==Introduction==
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==Description==
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An infectious disease caused by [[Erysipelothrix rhusiopathiae|''Erysipelothrix rhusiopathiae'']]. The disease is characterised by '''sudden death, septicaemia, [[:Category:Arthritis|arthritis]], [[Endocarditis|endocarditis]], diamond shaped skin lesions, laminitis''' and '''abortion''' in pregnant sows. Infection occurs via ingestion of contaminated food and water, or through skin abrasions. Swine Erysipelas is commonly called "Diamond skin disease".
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An infectious disease caused by [[Erysipelothrix rhusiopathiae|Erysipelothrix rhusiopathiae]]. Affects mainly growing pigs causing septicaemia, [[Joints Inflammatory - Pathology#Arthritis|arthritis] and laminitis.  
  
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==Signalment==
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*Carrier pigs act as reservoir of infection
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Affects pigs of all ages but is most common in pigs kept in poor conditions and also in batches of newly bought gilts. Often occurs during hot humid weather or in particular buildings or fields.
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*Organisms excreted in faeces of acutely-affected pigs
 +
*Ingestion of contaminated food and water, or via skin abrasions
 +
*Clinical outcome depends on susceptibility of pigs and virulence of strain
 +
*Pigs susceptible after maternal antibody waned (after 3 months) and before protective immunity acquired (3 years)
 +
*Change in diet, extremes of temperature and fatigue thought to predispose to infection
 +
*Septicaemic form:
 +
**Acute; incubation period 2-3 days
 +
**Pigs found dead, febrile, depressed, recumbent or with stilted gait
 +
**Mortality high
 +
**Pregant sows abort
 +
*Cutaneous form:
 +
**Diamond skin lesions
 +
**Fewer systemic signs, mortality rates lower
 +
**Pigs febrile with small, pink/purple raised areas or extensive diamond-shaped plaques over skin
 +
**Lesions may resolve within a week, or become necrotic and slough
 +
*Arthritis:
 +
**Older pigs, chronic
 +
**Stiffness, lameness, non-weight bearing on affected limbs
 +
**Joint lesions with erosion of articular cartilage, fibrosis and ankylosis
 +
**Strong impact on productivity
 +
*Chronic valvular endocarditis:
 +
**Vegetatic thrombosis of mitral valves
 +
**Asymptomatic or congestive heart failure and sudden death with stress
 +
*Diagnosis:
 +
**Diamond-shaped skin lesions
 +
**Haematology and post mortem, especially liver, [[Spleen - Anatomy & Physiology|spleen]], heart valves, synovial tissues
 +
**Slender Gram-positive rods on microscopy of acute lesions; filamentous forms in chronic lesions and smears
 +
**No growth on MacConkey agar
 +
**Colonial characteristics and biochemical tests
 +
*Treatment:
 +
**Penicillin and tetracyclines for acute infections
 +
**Hyperimmune serum
 +
*Control:
 +
**Hygience
 +
**Cull chronic cases
 +
**Isolate affected pigs
 +
**Live attenuated or inactivated vaccines
  
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==Diagnosis==
 
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Development of the '''typical diamond shaped lesion''' on the skin is '''pathognomic''' for this disease.  Erysipelas should be considered in any cases where '''fever and lameness occur together''', or in pregnant sows struggling to farrow in combination with a fever.
 
  
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===Clinical Signs===
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**Most important and most common cause of arthritis
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Clinical outcome depends on the susceptibility of the pig and the virulence of the strain of Erysipelas. Pigs are susceptible after maternal antibody has waned (after 3 months) and before protective immunity is acquired (3 years).
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**Causes '''chronic serofibrinous polyarthritis'''
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Changes in diet, extremes of temperature and fatigue are thought to predispose to infection.
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**Also causes '''discospondylitis'''
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3 forms of disease occur: Hyperacute, Acute and Chronic.
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***Similar to [[Joints Inflammatory - Pathology#In Dogs|discospondylitis in dogs]]
 +
**Thickening of synovial membrane lining + plus hyperaemia and villus formation + lymphocyte and plasma cell infiltration
 +
**Acute stage
 +
***Increased joint fluid + hot swollen joints
 +
***Also expresses as septicaemic and urticarial lesion on the back (diamond shaped)
 +
***May involve [[Endocarditis|endocarditis]] as a sequel
 +
**Chronic stage
 +
***More commonly encountered
 +
***Erosion of articular surface of joints with formation of [[Musculoskeletal Terminology - Pathology|pannus +/- joint ankylosis]]
 +
***Vaccination prevents septicaemic and urticarial forms but has no effect on joints
 +
****Probably due to dead bacteria still stimulating host immune system
 +
**Septicaemia lo9calises in meninges and joints
 +
**Well known in piglets in their first two months of life
 +
**Expresses as acute '''fibrinopurulent''' arthritis
  
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The '''hyperacute form''' is more common in younger pigs, who may present dull, collapsed or pyrexic with a scarlet tinge to the skin. This form can also present with cases of sudden death.
 
  
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In the '''acute form''', anorexia and pyrexia are the two most common clinical signs in younger pigs. Affected animals still die but normally after a day during which time they become dyspnoic. Older pigs tend to be pyrexic, anorexic and polydypsic.
 
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All pigs show, '''pink/purple raised areas or extensive diamond-shaped plaques''' over the skin within 24-48 hours of developing clinical signs. If pregnant sows are infected at this time they may abort.
 
  
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Following the '''chronic form''' of the disease, affected animals can completely recover, lesions often resolve within a week however they can become necrotic and slough.
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[[Category:Pig]][[Category:To_Do_-_Caz]]
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The bacteria localises in joints causing destruction of the synovial membrane lining, hyperaemia, villus formation and lymphocyte and plasma cell infiltration resulting in chronic serofibrinous polyarthritis.
 
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Initially joints are hot and swollen leading to stiffness, lameness, non-weight bearing on the affected limbs and eventual ankylosis. Discospondylitis can also occur if animals are chronically affected.
 
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Additionally valvular lesions may develop in the heart causing chronic valvular [[Endocarditis| endocarditis]], vegetative thrombosis of mitral valves and asymptomatic or congestive heart failure sometimes resulting in sudden death following stress.
 
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===Laboratory Tests===
 
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Slender Gram-positive rods  can be seen on microscopy of acute lesions and filamentous forms in  chronic lesions and on smears. High levels of antibody may be found in  joint fluid and so may aid diagnosis.
 
−
 
 
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[[ELISA  testing|ELISA]] and Polymerase Chain Reaction tests are also available  which can be used directly on tissue or following culture.
 
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===Pathology===
 
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Post mortem diagnosis may be needed for definitive diagnosis, in particular the, [[Liver - Anatomy & Physiology| liver]], [[Spleen - Anatomy & Physiology|spleen]], heart valves, [[Kidney Endocrine Function - Anatomy & Physiology| kidney]], a long bone and synovial tissues should be submitted for bacterial examination.
 
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====Gross====
 
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For hyperacute cases, typically no specific lesions are found except general congestion of the carcass and a change in skin colour.
 
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For acute cases there is often congestion of the carcass, in particular the spleen. The lungs are oedematous and petechiae may be found below the kidney, peritoneum and on the heart. Lymph nodes will also be swollen and haemorrhagic.
 
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Skin discolouration is also often present.
 
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For chronic cases, growths on heart valves may be evident as well as changes in joint architecture.  Joint capsules will be thickened in the presence of granulation tissue and in some cases erosion of articular surfaces may have progressed to ankylosis.
 
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Necrotic skin lesions may also be present.
 
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====Histologically====
 
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Vegetative lesions on the heart valves consist of connective and granulation tissue.
 
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Synovial lesions consist of macrophages and lymphocytes and short gram positive rods may be seen in smears made from blood in the heart.
 
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==Treatment==
 
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A 3 day course of [[Penicillins|Penicillin]]  or a [[Tetracyclines| tetracycline]]  is the treatment of choice and the response is normally rapid.
 
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Hyperimmune serum is also available however this is an expensive treatment option.
 
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==Control==
 
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Hygiene is very important to control Erysipelas including good sanitation and regular disinfection of pens.  It is advisable to cull chronic cases which will be acting as carrier pigs infecting other animals. Additionally, any pigs being treated should be isolated to reduce the spread of disease.
 
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Live attenuated or inactivated [[Vaccines|vaccines]] are also available. Immunity lasts for six months and the vaccine is normally given to recently weaned pigs and gilts or sows prior to service.
 
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==Prognosis==
 
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Varies from sudden death to recovery depending on the virulence of the strain and age and immune status of the affected pig.
 
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{{Learning
 
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|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Erysipelothrix+rhusiopathiae%22&occuring1=title&rowId=2&options2=OR&q2=Erysipelas&occuring2=title&rowId=3&options3=AND&q3=pigs&occuring3=od&x=49&y=6&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Erysipelas in pigs publications]
 
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|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2007/20073017454.pdf '''Swine erysipelas and human erysipeloid - a veterinary public health concern.''' Neelu Gupta; Vikas Gupta; Intas Pharmaceuticals Ltd, Ahmedabad, India, Intas Polivet, 2006, 7, 2, pp 341-347, 21 ref.]
 
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}}
 
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==References==
 
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Taylor D.J. (2006) '''Pig Diseases. 8th edition''' published by the author.
 
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{{review}}
 
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[[Category:Dermatological Diseases - Pig]][[Category:Reproductive Diseases - Pig]][[Category:Musculoskeletal Diseases - Pig]][[Category:Cardiovascular Diseases - Pig]]
 
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[[Category:Brian Aldridge reviewing]]
 
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[[Category:Cardiology Section]]
 

Revision as of 22:53, 25 July 2010

Template:Unfinshed

Description

An infectious disease caused by Erysipelothrix rhusiopathiae. Affects mainly growing pigs causing septicaemia, [[Joints Inflammatory - Pathology#Arthritis|arthritis] and laminitis.

  • Carrier pigs act as reservoir of infection
  • Organisms excreted in faeces of acutely-affected pigs
  • Ingestion of contaminated food and water, or via skin abrasions
  • Clinical outcome depends on susceptibility of pigs and virulence of strain
  • Pigs susceptible after maternal antibody waned (after 3 months) and before protective immunity acquired (3 years)
  • Change in diet, extremes of temperature and fatigue thought to predispose to infection
  • Septicaemic form:
    • Acute; incubation period 2-3 days
    • Pigs found dead, febrile, depressed, recumbent or with stilted gait
    • Mortality high
    • Pregant sows abort
  • Cutaneous form:
    • Diamond skin lesions
    • Fewer systemic signs, mortality rates lower
    • Pigs febrile with small, pink/purple raised areas or extensive diamond-shaped plaques over skin
    • Lesions may resolve within a week, or become necrotic and slough
  • Arthritis:
    • Older pigs, chronic
    • Stiffness, lameness, non-weight bearing on affected limbs
    • Joint lesions with erosion of articular cartilage, fibrosis and ankylosis
    • Strong impact on productivity
  • Chronic valvular endocarditis:
    • Vegetatic thrombosis of mitral valves
    • Asymptomatic or congestive heart failure and sudden death with stress
  • Diagnosis:
    • Diamond-shaped skin lesions
    • Haematology and post mortem, especially liver, spleen, heart valves, synovial tissues
    • Slender Gram-positive rods on microscopy of acute lesions; filamentous forms in chronic lesions and smears
    • No growth on MacConkey agar
    • Colonial characteristics and biochemical tests
  • Treatment:
    • Penicillin and tetracyclines for acute infections
    • Hyperimmune serum
  • Control:
    • Hygience
    • Cull chronic cases
    • Isolate affected pigs
    • Live attenuated or inactivated vaccines


    • Most important and most common cause of arthritis
    • Causes chronic serofibrinous polyarthritis
    • Also causes discospondylitis
    • Thickening of synovial membrane lining + plus hyperaemia and villus formation + lymphocyte and plasma cell infiltration
    • Acute stage
      • Increased joint fluid + hot swollen joints
      • Also expresses as septicaemic and urticarial lesion on the back (diamond shaped)
      • May involve endocarditis as a sequel
    • Chronic stage
      • More commonly encountered
      • Erosion of articular surface of joints with formation of pannus +/- joint ankylosis
      • Vaccination prevents septicaemic and urticarial forms but has no effect on joints
        • Probably due to dead bacteria still stimulating host immune system
    • Septicaemia lo9calises in meninges and joints
    • Well known in piglets in their first two months of life
    • Expresses as acute fibrinopurulent arthritis
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