Difference between revisions of "Glasser's Disease"

Revision as of 11:06, 27 July 2010

Description

Glasser's disease is caused by the bacteria Haemophilus parasuis. It is a systemic condition affecting pigs characterised by polyserositis, arthritis and meningitis. It is rapidly fatal in the acute form, in some cases animals die before the development of lesions.

Signalment

The disease usually affects weanlings 6-10 weeks old when maternal antibodies wane but it can affect pigs of any age, particularly naive pigs introduced into a herd or through exposure to a strain to which there is little immunity.

The disease occurs worldwide, it is endemic in most herds but incidence of clinical disease in the UK is sporadic.Increased prevelance hgas been associated with PRRS, Circovirus and Swine Influenza.

Diagnosis

Clinical signs

Pyrexia
Dyspneoa with abdominal effort
Cough
Swollen joints and arthritis
CNS signs, Trembling and paddling
Sudden death

Pathology

Treatment

Prognosis

References

May cause suppurative broncho pneumonia and pleuritis (as part of polyserositis)
Stress of mixing, weaning and adverse environmental conditions are predisposing to the disease

- Septicaemia
- Acute inflammation affecting pleura, peritoneum, mediastinum, pericardium, joints and meninges
- Causes a polyserositis - pericarditis, peritonitis, pleurisy and meningitis
- Also causes suppurative bronchopneumonia, pleuritis, polyarthritis (also H. suis)

- Fever, general malaise, repsiratory and abdominal signs, lameness, paralysis or convulsions. Expressed lesions vary between animals - meningitis is most consistent, arthritis in 20% of cases

- Sporadic outbreaks in the UK
- Morbidity and mortality often low due to widespread acquired resistance
- Mortality up to 50% in some outbreaks e.g. specific pathogen-free herds
- Can be fatal in 2-5 days
- Chronic arthritis, meningitis and intestinal obstruction due to adhesions in some surviving pigs
- Due to transport, environmental stresses, dietary and managemental factors
Fibrinous pneumonia secondary to enzootic pneumonia or virus infection e.g. swine influenza

Also known as:

b

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-==Introduction==
+{{unfinished}}
+{| cellpadding="10" cellspacing="0" border="1"
+| Also known as:
+| '''b<br>
+|-}
+==Description==
 '''Glasser's disease''' is caused by the bacteria ''[[Haemophilus parasuis]]''.
-It is a systemic condition affecting young pigs characterised by '''polyserositis, arthritis''' and '''meningitis'''. It is rapidly fatal in the acute form, in some cases animals die before the development of obvious lesions. In older pigs respiratory signs are most common such as bronchitis. Other syndromes may also occur.
+It is a systemic condition affecting pigs characterised by polyserositis, arthritis and meningitis. It is rapidly fatal in the acute form, in some cases animals die before the development of lesions.
 ==Signalment==
-The disease usually affects weanlings '''6-10 weeks old''' when maternal antibodies wane but it can affect pigs of any age, particularly naive pigs introduced into a herd or through exposure to a strain to which there is little immunity. The stress of mixing, weaning and adverse environmental conditions are predisposing factors.
+The disease usually affects weanlings '''6-10 weeks old''' when maternal antibodies wane but it can affect pigs of any age, particularly naive pigs introduced into a herd or through exposure to a strain to which there is little immunity.
+The disease occurs '''worldwide''', it is endemic in most herds but incidence of clinical disease in the UK is sporadic.Increased prevelance hgas been associated with [[Porcine Reproductive and Respiratory Syndrome|PRRS]], [[Porcine Circoviruses|Circovirus]] and [[Swine Influenza|Swine Influenza.]]
-The disease occurs '''worldwide''', it is endemic in most herds but incidence of clinical disease in the UK is sporadic due to widespread acquired resistance. Increased prevalence has been associated with [[Porcine Reproductive and Respiratory Syndrome|PRRS]], [[Porcine Circoviruses|Circovirus]] and [[Swine Influenza|Swine Influenza.]]
+==Diagnosis==
-Mortality is high where there is no immunity, for example outbreaks in specific pathogen-free herds.
-==Diagnosis==
 ===Clinical signs===
 *Pyrexia
-*Dyspnoea with abdominal effort
+*Dyspneoa with abdominal effort
-*Anorexia
 *Cough
 *Swollen joints and arthritis
-*CNS signs, trembling and paddling
+*CNS signs, Trembling and paddling
 *Sudden death
-Clinical signs develop rapidly; the disease is often fatal within 2-5 days. The skin becomes discoloured, turning red to blue before death. Expressed lesions vary between animals.
-Survivors or those affected by the chronic form of the disease show less severe clinical signs of weight loss and depression, they become lame with arthritis, develop congestive [[:Category:Heart Failure|heart failure]], [[Pericarditis|pericarditis]] or intestinal obstruction due to formation of adhesions. Pregnant sows may abort their fetuses.
 ===Pathology===
-On post mortem examination there is obvious pericarditis, [[Peritonitis|peritonitis]] and [[Pleuritis|pleuritis]] The lesions may be fibrinous with adhesions and thrombi.
-In cases of fibrinous pericarditis there will also be signs of congestive heart failure such as pulmonary oedema, cardiomegally and hepatomegally.
-The lungs show signs of suppurative bronchopneumonia and pleuritis.
-Purulent meningitis is often present.
-There is also polyarthritis of the joints, they are inflamed with turbid yellow joint fluid and fibrin deposits in the joint cavity.
 ==Treatment==
-Early treatment with parenteral antibiotics can be successful. [[Penicillins|Penicillin-streptomycin]], ampicillin, oxytetracycline and [[Potentiated-Sulphonamides|potentiated sulphonamides]] are all effective.
-Medicated water or feed for the duration of an outbreak will prevent the spread of the disease throughout the herd.
-==Prevention==
+==Prognosis==
-An inactivated vaccine is available for protection against Glasser's disease, two doses should be given by IM injection 2-3 weeks apart before 10 weeks of age.
-Other preventative measures include good management practice, minimising stress, avoiding mixing of age groups and the appropriate vaccination and isolation of naive stock being introduced to the herd.
+==References==
-==Prognosis==
+*May cause suppurative [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|broncho]][[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]] and [[Pleural Cavity & Membranes Inflammatory - Pathology|pleuritis]] (as part of polyserositis)
-The prognosis is poor. Treatment must be early if it is to be effective. In many cases the disease is too severe to treat and euthanasia is recommended on welfare grounds.
+*Stress of mixing, weaning and adverse environmental conditions are predisposing to the disease
-==Literature Search==
+**Septicaemia
-[[File:CABI logo.jpg|left|90px]]
+**Acute inflammation affecting pleura, peritoneum, mediastinum, pericardium, joints and meninges
+**Causes a polyserositis - pericarditis, [[Peritonitis|peritonitis]], pleurisy and meningitis
+**Also causes suppurative [[Respiratory Bacterial Infections - Pathology#Glasser's disease|bronchopneumonia, pleuritis]],  [[Joints Inflammatory - Pathology#In Pigs|polyarthritis]] (also ''H. suis)
+**Fever, general malaise, repsiratory and abdominal signs, lameness, paralysis or convulsions. Expressed lesions vary between animals - meningitis is most consistent, arthritis in 20% of cases
-Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
+**Sporadic outbreaks in the UK
-<br><br><br>
+**Morbidity and mortality often low due to widespread acquired resistance
-[http://www.cabdirect.org/search.html?start=0&q=title%3A%28glasser%27s%29+AND+title%3A%28disease%29 Glasser's disease publications]
+**Mortality up to 50% in some outbreaks e.g. specific pathogen-free herds
+**Can be fatal in 2-5 days
+**Chronic arthritis, meningitis and intestinal obstruction due to adhesions in some surviving pigs
+**Due to transport, environmental stresses, dietary and managemental factors
+*Fibrinous pneumonia secondary to enzootic pneumonia or virus infection e.g. swine influenza
-==References==
+[[Category:Pig]]
-* Jackson, G.G. and Cockcroft, P.D. (2007) '''Handbook of Pig Medicine''' ''Saunders Elsevier''
-* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
-* Taylor, D.J. (2006) '''Pig Diseases''' (Eighth edition) ''St Edmunsdbury Press  ltd''
-{{review}}
-[[Category:Musculoskeletal Diseases - Pig]][[Category:Neurological Diseases - Pig]][[Category:Respiratory Diseases - Pig]]
 [[Category:Respiratory_Bacterial_Infections]]
+[[Category:To_Do_-_lizzyk]]
-[[Category:Brian Aldridge reviewing]]