Difference between revisions of "Ragwort Toxicity"
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| − | Also known as: '''''Senecio jacobea'' toxicity | + | |
| + | Also known as:'''''Senecio jacobea'' toxicity | ||
[[Image:Ragwort.JPG|thumb|right|250px|<p>'''Ragwort''']] | [[Image:Ragwort.JPG|thumb|right|250px|<p>'''Ragwort''']] | ||
==Introduction== | ==Introduction== | ||
'''Ragwort''' (''Senecio jacobea'') is part of the daisy family, a flowering plant with completely yellow flowerheads. It commonly grows on wasteland and grazing pastures. | '''Ragwort''' (''Senecio jacobea'') is part of the daisy family, a flowering plant with completely yellow flowerheads. It commonly grows on wasteland and grazing pastures. | ||
| − | It is poisonous to livestock with | + | It is poisonous to livestock with Horses and cattle being more susceptible than sheep. When ingested over long periods of time it causes hepatotoxicity which in the severe form is invariably fatal. Exposure to the toxin is usually via ingestion of contaminated hay or silage as the animal will avoid it in the fresh form. |
The toxin is a '''pyrrolizidine alkaloid''' which is converted in the body to the toxic intermediate '''pyrroles''' and their esters which cause intitial and continued damage to hepatocytes. They have an anti-mitotic effect whilst allowing continued synthesis within the cell and its nucleus resulting in a marked increase in the size of the hepatocytes. The attempted repair by fibrosis aids the shunting from the portal triads to the central vein, thereby bypassing the hepatocytes and resulting in the clinical signs associated with liver failure. | The toxin is a '''pyrrolizidine alkaloid''' which is converted in the body to the toxic intermediate '''pyrroles''' and their esters which cause intitial and continued damage to hepatocytes. They have an anti-mitotic effect whilst allowing continued synthesis within the cell and its nucleus resulting in a marked increase in the size of the hepatocytes. The attempted repair by fibrosis aids the shunting from the portal triads to the central vein, thereby bypassing the hepatocytes and resulting in the clinical signs associated with liver failure. | ||
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===Clinical signs=== | ===Clinical signs=== | ||
*Weight loss | *Weight loss | ||
| − | * | + | *Annorexia |
*Hepatic insufficiency | *Hepatic insufficiency | ||
*Hepatic encephalopathy | *Hepatic encephalopathy | ||
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Horses with chronic liver failure due to ragwort poisoning have a poor prognosis for survival as the damage to the liver is severe by the time clinical signs are obvious. | Horses with chronic liver failure due to ragwort poisoning have a poor prognosis for survival as the damage to the liver is severe by the time clinical signs are obvious. | ||
| − | + | ==Test yourself with the Liver Pathology Flashcards== | |
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| − | + | [[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]] | |
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| + | ==Literature Search== | ||
| + | [[File:CABI logo.jpg|left|90px]] | ||
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| + | Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation). | ||
| + | <br><br><br> | ||
| + | [http://www.cabdirect.org/search.html?q=%28title%3A%28Ragwort%29+OR+title%3A%28%22Senecio+jacobaea%22%29%29+AND+%28title%3A%28tox*%29+OR+title%3A%28intox*%29%29 Ragwort Toxicity publication] | ||
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==References== | ==References== | ||
* Knottenbelt, D.C. '''A Handbook of Equine Medicine for Final Year Students''' ''University of Liverpool'' | * Knottenbelt, D.C. '''A Handbook of Equine Medicine for Final Year Students''' ''University of Liverpool'' | ||
*Rose, R. J. and Hodgson, D. R. (2000) '''Manual of Equine Practice''' (Second Edition) Sauders. | *Rose, R. J. and Hodgson, D. R. (2000) '''Manual of Equine Practice''' (Second Edition) Sauders. | ||
| − | + | [[Category:Hepatotoxicity, Chronic]][[Category:Liver_Disorders_-_Horse]][[Category:Sheep]] | |
| − | + | [[Category:To_Do_- lizzyk]] | |
| − | + | [[Category:Expert_Review]] | |
| − | + | [[Category:Cattle]] | |
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| − | [[Category:Hepatotoxicity, Chronic]] | ||
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Revision as of 15:37, 4 October 2010
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Also known as:Senecio jacobea toxicity
Introduction
Ragwort (Senecio jacobea) is part of the daisy family, a flowering plant with completely yellow flowerheads. It commonly grows on wasteland and grazing pastures. It is poisonous to livestock with Horses and cattle being more susceptible than sheep. When ingested over long periods of time it causes hepatotoxicity which in the severe form is invariably fatal. Exposure to the toxin is usually via ingestion of contaminated hay or silage as the animal will avoid it in the fresh form.
The toxin is a pyrrolizidine alkaloid which is converted in the body to the toxic intermediate pyrroles and their esters which cause intitial and continued damage to hepatocytes. They have an anti-mitotic effect whilst allowing continued synthesis within the cell and its nucleus resulting in a marked increase in the size of the hepatocytes. The attempted repair by fibrosis aids the shunting from the portal triads to the central vein, thereby bypassing the hepatocytes and resulting in the clinical signs associated with liver failure.
Signalment
Hepatotoxicity due to ragwort poisoining occurs mainly in horses and cattle grazing highly contaminated pastures or contaminated roughage over long periods of time.
Diagnosis
Clinical signs
- Weight loss
- Annorexia
- Hepatic insufficiency
- Hepatic encephalopathy
Biochemistry
Rasised liver enzymes (AST, GGT, AP and LDH) and elevated bilirubin and bile acids indicate liver disease, however in very severe, chronic cases where active damage is no longer occurring, liver enzymes may be normal.
Biopsy
A liver biopsy will reveal hepatomegalocytosis and bilary hyperplasia.
Post Mortem
On gross post mortem examination the liver is small, dense and fibrotic with prominent biliary tracts.
Treatment
There is no corrective treatment for the liver damage caused by ragwort poisoning, supportive treatment can improve quality of life and minimise some of the clinical signs by reducing the workload of the liver. Small, frequent feeds should be given 6 times a day and should consist of a high quality energy and protein source. Stomach tubing may be necessary if the horse is inappetent. Supplementary B vitamins may also be beneficial and can be given orally or parenterally.
Prognosis
Horses with chronic liver failure due to ragwort poisoning have a poor prognosis for survival as the damage to the liver is severe by the time clinical signs are obvious.
Test yourself with the Liver Pathology Flashcards
Literature Search
Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
Ragwort Toxicity publication
References
- Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool
- Rose, R. J. and Hodgson, D. R. (2000) Manual of Equine Practice (Second Edition) Sauders.