Difference between revisions of "Aspergillosis"

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Image:Aspergillus pneumonia of cattle.jpg|<center><p>'''Aspergillus hyphae in cattle lung'''</p><sup> (Image sourced from Bristol Biomed Image Archive with permission)</center></small>
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Image:Aspergillus pneumonia of cattle.jpg|<center><p>'''Aspergillus hyphae in cattle lung'''</p><sup> (Image sourced from Bristol Biomed Image Archive with permission)
Image:Aspergillosis in nasal cavity.jpg|<center><p>'''Nasal aspergillosis'''</p><sup> (Image sourced from Bristol Biomed Image Archive with permission)</center></small>
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Image:Aspergillosis in nasal cavity.jpg|<center><p>'''Nasal aspergillosis'''</p><sup> (Image sourced from Bristol Biomed Image Archive with permission)
  
 
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Revision as of 10:46, 18 August 2010



Description

Apergillosis is a disease of the respiratory system caused by several Aspergillus spp.. Aspergillus fumigatus is the most frequently reported species in domestic animals but Aspergillus tereus has also been implicated. The pathogen is a ubiquitous saprophyte and is found worldwide. Commonly affected species include birds, dogs, cats, horses and cattle but the disease has been reported in many other wild and domestic species.

Clinical signs and features

Birds

In avian species the disease manifests as a diffuse infection of the air sacs. Two forms of the disease have been reported; a diffuse pneumonic form and a nodular form involving the lungs. Clinical signs include dyspnoea, diarrhoes, listlessness, pyrexia, loss of appetite and loss of condition. Seizures and torticollis may occasionally occur if infection disseminates to the brain.

Cattle

Aspergillosis has a number of clinical manifestations in the cow including mastitis, abortion, placentitis, ocular infections and mycotic pneumonia. Cows usually abort in the second or third trimester of pregnancy, usually between the fifth and seventh month of gestation. Clinical signs include Lesions are usually up to 2mm in diameter and contain asteroid bodies with a germinated spore in the centre. Acute infection causes miliary lesions and chronic infections causes granulomatous and calcified lesions.

Horses

In the horse the guttural pouches are most commonly affected. Aspergillus infection may also lead to abortion.

Dogs

Aspergillosis is a common cause of nasal disease in dogs. Cases occur most commonly in young to middle aged male dogs, but animals of all age and of both sexes may be affected. Doliocephalic breeds are thought to be overrepresented. Clinical signs are those seens with any chronic nasal disease and include sneezing, unilateral or bilateral serosanguinous nasal discharge, ulceration of the nares, nasal pain and epistaxis. The disease is usually localised to the paranasal sinuses and nasal cavity but a disseminated form with granulomas and infarcts has been reported in dogs, particularly German Shephards. The disease often involves multiple organ systems including the spleen and kidneys. Clinical signs include lethargy, anorexia, haematuria, urinary incontinence and haematuria. The vertebrae are frequently affected and osteomyelitis and discospondlylitis are common features.

Diagnosis

In dogs, radiology is often peformed in the diagnostic work up of an animal with suspected Aspergillosis. Open-mouth ventro-dorsal views often reveal generalised radiolucency and lysis of the turbinate bones. Rhinoscopy may be used to directly visualise the lesions, revealing characteristic white-green fungal plaques. Fungal culture can be used to demonstrate the organism but should not be used as the sole means of diagnosis due to the ubitquitous nature of Aspergillus in the environment. Aspergillus grows on Sabauraud's Dextrose and Blood agar. White colonies form intitially which turn green, then dark green, flat and velvety


  • Microscopically:
    • Conidiophores with large terminal vesicles (only visible in the lungs and air sacs where there is access to oxygen)
      • Vesicle shape varies depending on the species
    • Is a common contaminant so repeated tests should be done for a definitive diagnosis



Treatment

In dogs, the treatment of choice is topical application of the anti-fungal agent Clotrimazole. It is admnistered via indwelling catheters placed through a trephine hole in the frontal sinus.


Aspergillus fumigatus

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Aspergillosis Flashcards