Changes

*Firstly [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]  

*Firstly [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]  

*-> death of satellite cells  

*-> death of satellite cells  

**Causes [[Muscle Regeneration - Anatomy & Physiology|regeneration]] but myoblast precursors have to be recruited from viable fibres

**Causes [[Muscle Regeneration|regeneration]] but myoblast precursors have to be recruited from viable fibres

*-> death of all cells

*-> death of all cells

*Mostly healed by fibrosis and scar formation

*Mostly healed by fibrosis and scar formation

*May attempt regeneration by [[Muscle Regeneration - Anatomy & Physiology|budding]]

*May attempt regeneration by [[Muscle Regeneration|budding]]

Main causes:

Main causes:

*'''Vascular occlusion'''

*'''Vascular occlusion'''

**Complete rupture - ''e.g.'' quadriceps of racing greyhounds

**Complete rupture - ''e.g.'' quadriceps of racing greyhounds

**Myorrhexis (tearing) - ''e.g.'' slippery floor causing 'splits' in cattle -> adductor muscle tear

**Myorrhexis (tearing) - ''e.g.'' slippery floor causing 'splits' in cattle -> adductor muscle tear

*Healing is by [[Muscle Regeneration - Anatomy & Physiology|regeneration]]

*Healing is by [[Muscle Regeneration|regeneration]]

*Fibrosis (scarring) will compromise function

*Fibrosis (scarring) will compromise function

*During [[Bones Fractures - Pathology|fractures]], fragments may cause further trauma if moved

*During [[Bones Fractures - Pathology|fractures]], fragments may cause further trauma if moved