Difference between revisions of "Category:Oesophagus - Pathology"

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====Bovine Papular Stomatitis====
 
  
===Neoplastic===
+
====[[Upper Alimentary Tract Carcinoma Complex]]====
====Upper Alimentary Tract Carcinoma Complex====
 
  
=====Aetiology=====
 
*The most important [[Oesophagus - Anatomy & Physiology|oesophageal]] neoplasm is squamous cell carcinoma in the cow.
 
*This tumour is seen as part of a more general syndrome of upper alimentary tract neoplasia in adult cattle grazing rough pasture on which the '''bracken fern''' (Pteridium aquilinum) is present.
 
*The syndrome is seen in various part of the world including the Western Highlands of Scotland, Brazil and Kenya.
 
*In affected animals, squamous carcinomas may be present in the [[Oral Cavity - Oropharynx - Anatomy & Physiology|oropharynx]], [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[The Rumen - Anatomy & Physiology|rumen]] and there may also be [[intestinal adenocarcinomas]] and bladder tumours, or the condition known as [[enzootic bovine haematuria]].
 
  
=====Pathogenesis=====
 
*Experimentally, the feeding of bracken to laboratory animals will result in alimentary and [[Urinary Bladder - Anatomy & Physiology|bladder]] tumours.
 
*However, in many naturally-occurring cases of upper alimentary carcinoma in cattle there are coexisting viral papillomata, some of which show malignant change.
 
*The relationship between the ingestion of bracken and the presence of virus in the aetiology of the malignancies is currently the subject of intensive investigations.
 
*It may be that both are involved in the carcinogenesis.
 
  
=====Macroscopically=====
+
====[[Squamous Cell Carcinoma]] of Other Species====
*These upper alimentary squamous carcinomas are most often seen as:
 
**large
 
**fungating
 
**often superficially-necrotic
 
**protruding into the lumen of the [[Alimentary - Anatomy & Physiology|alimentary tract]];
 
*There is often a marked scirrhous reaction.
 
*The tumours are locally aggressive and may permeate local lymphatics and metastasise to local lymph nodes.
 
 
 
=====Microscopically=====
 
The tumour consists of cords or groups of squamous cells, which may form keratin.
 
Individual or multiple papillomata may be found in association with the carcinomata.
 
*The presence of the tumours interferes with normal alimentary function
 
**there may be difficulty in chewing and [[Deglutition|swallowing]] or in cudding and [[Eructation - Anatomy & Physiology|eructation]].
 
 
 
====Squamous Cell Carcinoma of Other Species====
 
 
*Squamous cell carcinomas of the [[Oesophagus - Anatomy & Physiology|oesophagus]] are occasionally seen in other species, notably in the cat, where the tumour tends to infiltrate around the oesophageal wall resulting in a “'''ring carcinoma'''”.  
 
*Squamous cell carcinomas of the [[Oesophagus - Anatomy & Physiology|oesophagus]] are occasionally seen in other species, notably in the cat, where the tumour tends to infiltrate around the oesophageal wall resulting in a “'''ring carcinoma'''”.  
 
*The affected cat has progressive difficulty in eating and [[Deglutition|swallowing]].
 
*The affected cat has progressive difficulty in eating and [[Deglutition|swallowing]].
 
+
*Forms part of [[Upper Alimentary Tract Carcinoma Complex]]
  
 
==Traumatic Pathology==
 
==Traumatic Pathology==

Revision as of 11:31, 28 May 2010



Introduction

  • The oesophagus is the part of alimentary tract that tends to go wrong least often.


  • Failure of oesophageal function results in obstruction and in failure of ingesta to pass to the stomach.
  • In the bovine there may also be failure of eructation and tympany may develop.

Defence Mechanisms

  • The oesophagus has no serosa and is covered by the fibrous tissue of the neck and mediastinum, from which it derives its blood supply.
  • Consequently, infection spreads easily and healing is more difficult.
  • Oesophageal disease is therefore difficult to treat and is consequently very serious.



Upper Alimentary Tract Carcinoma Complex

Squamous Cell Carcinoma of Other Species

  • Squamous cell carcinomas of the oesophagus are occasionally seen in other species, notably in the cat, where the tumour tends to infiltrate around the oesophageal wall resulting in a “ring carcinoma”.
  • The affected cat has progressive difficulty in eating and swallowing.
  • Forms part of Upper Alimentary Tract Carcinoma Complex

Traumatic Pathology

Impaction

Upper Block Lower Block
Acute vomiting Gradual intestinal distention
Dehydration Mucosal destruction
Alkalosis Toxaemia
Pre-renal azotaemia Peritonitis


  • Commonly in cattle, horses and dogs.
  • The most common sites of obstruction are the thoracic inlet, the base of the heart, and the hiatus oesophagus of the diaphragm, i.e.: the narrowest points.

Clinical Signs

Horse

  • With foods that expand in oesophagus such as haylage etc.
  • Also seen with whole apples.

Cattle

Impaction of a bovine oesophagus (Courtesy of Alun Williams (RVC))
  • May eat a spherical object that obstructs the oesophagus mostly in anterior 1/3rd of oesophagus and can often be palpated in live animal.
  • Potatoes can be a cheap source of feed and if fed whole can become stuck in oesophagus.
  • If obstruction occurs further down can be difficult to diagnose and remove.
  • Cattle develop bloat when oesophagus obstructed.
  • Apples fairly easily to dislodge.

Dog

  • Usually with small bones
  • Animals that feel protective of feed may gulp food down quickly, particularly if given small chops / knuckle bones.
  • Knobbly shape may make bone lodge in oesophagus, particularly just anterior to heart.
  • Very difficult to dislodge (because of shape).
  • Pressure necrosis occurs very quickly around it and can erode through oesophagus within about 24 hours.
  • Small bone may also lodge in duodenum if they pass through the stomach.

Rupture

  • Perforation may occur with sharp foreign bodies. This may lead to cellulitis or pleurisy and other complications.
  • Rupture of the oesophagus admits pathogenic organisms to the mediastinum and fascial planes of the neck. Both are composed of loose connective tissue and communicate with each other.
  • Infection spreads rapidly as a cellulitis, aided possibly by peristalsis and pulsation of the carotid arteries, and soon leads to pleurisy.
  • Rupture is almost always fatal.


Learning Tools

Oesophagus Flashcards