Category:Primary Adaptive Immunity Deficiencies

Deficiencies of Adaptive Immunity

Equine Severe Combined Immune Deficiency

Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)

• Affects Basset Hounds and Corgis
• X-linked recessive defect in the gene coding for the IL-2 receptor
  • IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
• Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
• Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases

Selective IgA deficiency of German Shepherd Dogs

• Poorly understood
• Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
• [[Immunoglobulin A|IgA]] deficiency so more susceptible to mucosal disease

Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds

• Unknown aetiology
• Inherited defects
• Low levels of circulating IgM and IgG
• Impaired neutrophil function
• Causes recurrent pyrexia and infections
  • E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|IgA]]
  • E.g. Pneumocytosis in Miniature Dachshunds due to low IgG