Eosinopaenia refers to a reduction in the normal number of circulating blood eosinophils. It ocurs most commonly as part of a stress leucocgram and in other situations that result in an increase in the circulating concentration of glucocorticoids:
- Stress leucogram, with which neutrophilia, monocytosis and lymphopaenia would also be expected.
- Hyperadrenocorticism (Cushing's disease) results in a similar pattern due to an increase in endogenous glucocorticoids.
- Iatrogenic hyperadrenocorticism caused by the administration of corticosteroids, even with the use of topical otic or ophthalmic preparations.
Corticosteroids are thought to exert a depressive effect on lymphocytes which usually stimulate eosinophil production.
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