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Eosinopaenia refers to a reduction in the normal number of circulating blood eosinophils. It ocurs most commonly as part of a stress leucocgram and in other situations that result in an increase in the circulating concentration of glucocorticoids:

  • Stress leucogram, with which neutrophilia, monocytosis and lymphopaenia would also be expected.
  • Hyperadrenocorticism (Cushing's disease) results in a similar pattern due to an increase in endogenous glucocorticoids.
  • Iatrogenic hyperadrenocorticism caused by the administration of corticosteroids, even with the use of topical otic or ophthalmic preparations.

Corticosteroids are thought to exert a depressive effect on lymphocytes which usually stimulate eosinophil production.

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Eosinopaenia mentioned in abstract of publications

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