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Bone Response to Damage (view source)
Revision as of 07:51, 10 October 2007
, 07:51, 10 October 2007no edit summary
***Mesenchymal cells
***Mesenchymal cells
***Arise from bone marrow stroma
***Arise from bone marrow stroma
***Histologically:
****Plump and cuboidal when active
****Basophilic cytoplasm
****When inactive - less cytoplasm -> flattened
***Produce bone matrix = '''osteoid''' - uncalcified
***Produce bone matrix = '''osteoid''' - uncalcified
****Homogeneous substance
****Homogeneous substance
****Stains light pink with H&E
****Stains light pink with H&E
***Cell membranes are rich in alkaline phosphatase (ALP)
***Cell membranes are rich in alkaline phosphatase (ALP)
****Possibly involved in pumping calcium across membranes
***Promoted by growth factors
***Promoted by growth factors
***Plump, cuboidal basophilic cells
***Have receptors for PTH
**'''Osteocytes'''
**'''Osteocytes'''
***Osteoblasts that have become surrounded by mineralised bone matrix
***Osteoblasts that have become surrounded by mineralised bone matrix