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== Introduction ==
== Introduction ==
Basophils are derived from the same stem cell line as [[Mast Cells|mast cells]] and while they are similar to mast cells, they are not identical (they are thought by some to be immature mast cells). They are the least common of all the [[Leukocytes|leukocytes]], are a similar size to neutrophils and eosinophils and are characterised by the large number of basophilic staining granules in their cytoplassm. They are present in the circulation but rarely found in tissue.
Basophils are derived from the same stem cell line as [[Mast Cells|mast cells]] and while they are similar to mast cells, they are not identical (they are thought by some to be immature mast cells). They are the least common of all the [[Leukocytes|leukocytes]], are a similar size to neutrophils and eosinophils and are characterised by the large number of basophilic staining granules in their cytoplasm. They are present in the circulation but rarely found in tissue.
== Development ==
== Development ==
== Actions ==
== Actions ==
Fc receptors on the basophil surface binds with IgE formed during allergic reactions and causes them to degranulate. The vasoactive substances released from the granules causes vasodialtion allowing for the infiltration of other leukocytes i.e. [[Neutrophils#Movement|neutrophil diapedesis]].
Fc receptors on the basophil surface binds with IgE formed during allergic reactions and causes them to degranulate. The vasoactive substances released from the granules causes vasodilation allowing for the infiltration of other leukocytes i.e. [[Neutrophils#Movement|neutrophil diapedesis]].
=== Role in pathology ===
=== Role in pathology ===
*[[IgE]] and CD40 receptors on the basophils interact with B cells to increase [[IgE]] production
*[[IgE]] and CD40 receptors on the basophils interact with B cells to increase [[IgE]] production
*Il-8 released by [[Neutrophils|neutrophils]] attracts basophils
*IL-8 released by [[Neutrophils|neutrophils]] attracts basophils
*[[Complement]] factor C3a binds to the basophil and causes degranulation
*[[Complement]] factor C3a binds to the basophil and causes degranulation