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Riboflavin deficiency impairs growth rate in puppies<ref>Axelrod AE, et al. The production of uncomplicated riboflavin deficiency in the dogs. Am J Physiol 1940;128:703-708.</ref><ref name="Noel">Noel PR, et al. Riboflavin supplementation in the dog. Res Vet Sci 1972;13:443-450.</ref>, and can result in anorexia, weight loss, weakness, ataxia, collapse, and death<ref>Street HR and Cowgill GR. Acute riboflavin deficiency in the dog. Am J Physiol 1939;125:323-334.</ref>. Bilateral corneal opacities have also been described in adult dogs fed riboflavin deficient diets<ref name="Noel"/>.

Riboflavin deficiency impairs growth rate in puppies<ref>Axelrod AE, et al. The production of uncomplicated riboflavin deficiency in the dogs. Am J Physiol 1940;128:703-708.</ref><ref name="Noel">Noel PR, et al. Riboflavin supplementation in the dog. Res Vet Sci 1972;13:443-450.</ref>, and can result in anorexia, weight loss, weakness, ataxia, collapse, and death<ref>Street HR and Cowgill GR. Acute riboflavin deficiency in the dog. Am J Physiol 1939;125:323-334.</ref>. Bilateral corneal opacities have also been described in adult dogs fed riboflavin deficient diets<ref name="Noel"/>.

====Cats:====  

====Cats:====  

Riboflavin deficiency in cats can resulted in anorexia, weight loss, periauricular alopecia, bilateral cataracts, testicular hypoplasia, fatty accumulation in the liver, and death<ref>Gershoff SN, et al. The effect of the carbohydrate and fat content of the diet upon the riboflavin requirement of the cat. J Nutr 1959;68:75-88.</ref>.

Riboflavin deficiency in cats can resulted in anorexia, weight loss, periauricular [[alopecia]], bilateral cataracts, testicular hypoplasia, [[Hepatic Lipidosis|fatty accumulation in the liver]], and death<ref>Gershoff SN, et al. The effect of the carbohydrate and fat content of the diet upon the riboflavin requirement of the cat. J Nutr 1959;68:75-88.</ref>.

Conditions associated with diuresis (e.g., chronic disease, such as renal disease or [[Diabetes Insipidus|diabetes]], or therapeutic intervention, such as intravenous fluids or increased water intake with management of [[Cystitis|lower urinary diseases]]) can result in increased loss of riboflavin and may increase daily requirements. Patients on chronic haemodialysis are also at an increased risk for developing a deficiency.  

Conditions associated with diuresis (e.g. chronic disease, such as [[:Category:Kidney - Pathology|renal disease]] or [[Diabetes Insipidus|diabetes]], or therapeutic intervention, such as intravenous fluids or increased water intake with management of [[Cystitis|lower urinary diseases]]) can result in increased loss of riboflavin and may increase daily requirements. Patients on chronic haemodialysis are also at an increased risk for developing a deficiency.  

Riboflavin deficiencies can also occur due to low dietary intake and vitamin degradation during cooking especially under alkaline conditions.

Riboflavin deficiencies can also occur due to low dietary intake and vitamin degradation during cooking especially under alkaline conditions.

==Diagnosing Riboflavin Deficiency==

==Diagnosing Riboflavin Deficiency==

Diagnosis of riboflavin deficiency is based on a finding of low erythrocyte glutathione reductase activity, although this is not routinely tested for in veterinary reference laboratories. A clinical suspicion arises when there are clinical signs consistent with a riboflavin deficiency and dietary analysis indicates a deficiency.  

Diagnosis of riboflavin deficiency is based on a finding of low [[Erythrocytes|erythrocyte]] glutathione reductase activity, although this is not routinely tested for in veterinary reference laboratories. A clinical suspicion arises when there are clinical signs consistent with a riboflavin deficiency and dietary analysis indicates a deficiency.

==References==

==References==

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[[Category:Vitamins]]

[[Category:Vitamins]]