Difference between revisions of "Category:Primary Adaptive Immunity Deficiencies"

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(Created page with "===Deficiencies of Adaptive Immunity=== ====Equine Severe Combined Immune Deficiency (Equine SCID)==== *Autosomal recessive *Occurs in 2-3% of Arabian foals *Defect in DNA-depen...")
 
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===Deficiencies of Adaptive Immunity===
 
===Deficiencies of Adaptive Immunity===
  
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====Equine Severe Combined Immune Deficiency (Equine SCID)====
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====[[Equine Severe Combined Immune Deficiency]] ====
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*Autosomal recessive
 
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*Occurs in 2-3% of Arabian foals
 
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*Defect in DNA-dependent protein kinase gene
 
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**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
 
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*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
 
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*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
 
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*Foals usually die from bronchopneumonia
 
  
 
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
 
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
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*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:To Do - Blood]]
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
*Poorly understood
 
*Poorly understood
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:To Do - Blood]]
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
 
*Unknown aetiology
 
*Unknown aetiology
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**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
 
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
 
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
 
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:To Do - Blood]]
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[[Category:Primary Immunodeficiency]]
 
[[Category:Primary Immunodeficiency]]

Revision as of 13:53, 12 August 2010

Deficiencies of Adaptive Immunity

Equine Severe Combined Immune Deficiency

Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)

  • Affects Basset Hounds and Corgis
  • X-linked recessive defect in the gene coding for the IL-2 receptor
    • IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
  • Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
  • Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases

Selective IgA deficiency of German Shepherd Dogs

  • Poorly understood
  • Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
  • [[Immunoglobulin A|IgA]] deficiency so more susceptible to mucosal disease

Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds

  • Unknown aetiology
  • Inherited defects
  • Low levels of circulating IgM and IgG
  • Impaired neutrophil function
  • Causes recurrent pyrexia and infections
    • E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|IgA]]
    • E.g. Pneumocytosis in Miniature Dachshunds due to low IgG
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