Difference between revisions of "Cryptococcosis"

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m (Text replace - "[[Cardiorespiratory System - Anatomy & Physiology|" to "[[Cardiorespiratory System Overview - Anatomy & Physiology|")
m (Text replace - "Paranasal sinuses - Anatomy & Physiology|" to "Paranasal Sinuses - Anatomy & Physiology|")
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*Targets the [[Cardiorespiratory System Overview - Anatomy & Physiology|respiratory system]]
 
*Targets the [[Cardiorespiratory System Overview - Anatomy & Physiology|respiratory system]]
**Including the [[Paranasal sinuses - Anatomy & Physiology|paranasal sinuses]]
+
**Including the [[Paranasal Sinuses - Anatomy & Physiology|paranasal sinuses]]
 
**Also can be systemic, cutaneous, visceral, skeletal or ocular
 
**Also can be systemic, cutaneous, visceral, skeletal or ocular
  
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*Affects the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] of dogs and cats
 
*Affects the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] of dogs and cats
**[[Paranasal sinuses - Anatomy & Physiology|paranasal sinuses]] and [[Pharynx - Anatomy & Physiology|pharynx]] can be infected with dissemination to the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] and other tissues
+
**[[Paranasal Sinuses - Anatomy & Physiology|paranasal sinuses]] and [[Pharynx - Anatomy & Physiology|pharynx]] can be infected with dissemination to the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] and other tissues
 
***E.g. [[Lungs - Anatomy & Physiology|Lungs]], [[Urinary System - Anatomy & Physiology#The Kidney|kidneys]] and [[Joints - Anatomy & Physiology|joints]]
 
***E.g. [[Lungs - Anatomy & Physiology|Lungs]], [[Urinary System - Anatomy & Physiology#The Kidney|kidneys]] and [[Joints - Anatomy & Physiology|joints]]
 
**Also causes subcutaneous granulomas
 
**Also causes subcutaneous granulomas

Revision as of 13:10, 10 September 2010

  • Over 19 species
    • C. neoformans only major pathogen
  • Worldwide
  • Occurs in high concentrations in pigeon droppings (high creatinine concentration)
    • The pigeon is not infected
    • C. neoformis colonise the droppings after they have been excreted
    • Also found in fruit, milk and soil
  • Exogenous, inhaled infection which is generally sporadic (non-contageous)
    • Can also be absorbed via skin penetration and ingestion
  • May be a primary pathogen or opportunistic
  • Causes sporadic mastitis in cattle
    • Can spread within the herd
  • Affects the CNS of dogs and cats
  • Causes myxoma-like lesions of the lung and lip in horses
  • Causes cryptococcal meningitis in humans
  • Also affects dolphins, foxes, ferrets, monkeys, birds, cheetahs and guinea-pigs
  • Large yeast with capsule seen using India ink stain
  • Stains with PAS (Periodic acis Schiff)
  • Gram positive
  • Grows on blood agar and Sabouraud's Dextrose agar forming white, granular colonies which become slimy, mucoid and turn creamy/brown within a week
  • Species identified by carbohydrate assimilation tests
  • Antigen and antibody should be tested for as antibody formed by the body is soon overwhelmed and neutralised by abundent polysaccharide antigen from the capsule in active, systemic infections
    • Latex agglutination for antigen, complement fixation, ELISA and IFAT can be used

Test yourself with the Yeast-like Fungi Flashcards

Cryptococcosis Flashcards

Links

Cryptococcus neoformans