Difference between revisions of "Viral skin infections - Pathology"
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| Line 63: | Line 63: | ||
*Cutaneous lesion are seen with: | *Cutaneous lesion are seen with: | ||
**[[Picornaviridae]] | **[[Picornaviridae]] | ||
| − | ***[[ | + | ***[[Foot and Mouth Disease|Foot-and-mouth disease]] |
| − | ***[[ | + | ***[[Swine Vesicular Disease|Swine vesicular disease]] |
**[[Rhabdoviridae]] | **[[Rhabdoviridae]] | ||
***Vesicular stomatitis | ***Vesicular stomatitis | ||
Revision as of 13:30, 28 May 2010
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Herpesviruses
- Cutaneous lesions may develop with nondermatotropic viruses:
- Infectious bovine rhinotracheitis (bovine herpes virus - 1)
- Equine coital exanthema (equine herpes virus - 3)
- Feline herpes virus -1 (rarely)
- Dermatotropic viruses:
- Bovine herpes virus - 2 = Bovine herpes mammillitis virus
- May cause generalised disease - pseudolumpy skin
- Localised disease - bovine herpes mammillitis
- Mostly in lactating cows
- Skin trauma is essential for virus invasion
- Decreased milk production and secondary bacterial mastitis
- Lesion occur on teats, udder, sometimes perineum, on muzzle of suckling calves
- Bovine herpes virus - 4 = Bovine herpes mammary pustular dermatitis
- Similar to localised BHV-2 but milder disease
- Bovine herpes virus - 2 = Bovine herpes mammillitis virus
- May be latent and reappear at times of stress
- Grossly:
- Microscopically:
- Intraepidermal vesicle
- Epidermal cell degeneration
- Acantholysis
- Syncytial cells may form
- Intracellular inclusion bodies may be found at edges of ulcers
- Rapid necrosis
Poxviruses
- Lesion development:
- Due to viral invasion of epithelium
- Vascular injury -> ischaemic necrosis
- Stimulation of host DNA -> hyperplastic nodules
- Cutaneous lesions:
Contagious ecthyma
- Also called contagious pustular dermatitis, orf, sore mouth
- Caused by a parapox virus
- Affects mainly young sheep, less commonly cattle, humans, dogs
- Starts in abrasions around mouth commisures and spreads to lips, oral mucosa, eyelids and feet
- May also transfer to teats of the mother of an affected lamb
- Lesions typical of poxvirus but very brief vesicle stage
- Most obvious is the proliferative pustular stage
Other viruses
- Cutaneous lesion are seen with:
- Picornaviridae
- Rhabdoviridae
- Vesicular stomatitis
- Caliciviridae
- Vesicular exanthema
- Retroviridae
- Feline leukemia virus
- Cutaneous horns on foot pads
- Epidermal and follicular epithelial hyperplasia, epidermal giant cells, dyskeratosis, necrosis, ulceration
- Feline immunodeficiency virus
- Feline leukemia virus