Difference between revisions of "Protein Losing Enteropathy"

From WikiVet English
Jump to navigation Jump to search
m (Text replace - 'Intestine Diarrhoea - Pathology' to 'Diarrhoea')
Line 24: Line 24:
 
'''Protein-losing enteropathy (PLE)''' can result from any intestinal disease which produces sufficient [[Inflammation - Pathology|inflammation]], congestion or bleeding.  This causes protein to leak into the intestines, which exceeds capacity of the gut lumen protein synthesis.  Hence, there are numerous causes of PLE, including [[Lymphangiectasia - WikiClinical|lymphangiectasia]], infectious causes, structural causes, neoplasia, [[Inflammation - Pathology|inflammation]], endoparasites and gastrointestinal [[Haemorrhage - Pathology|haemorrhage]].   
 
'''Protein-losing enteropathy (PLE)''' can result from any intestinal disease which produces sufficient [[Inflammation - Pathology|inflammation]], congestion or bleeding.  This causes protein to leak into the intestines, which exceeds capacity of the gut lumen protein synthesis.  Hence, there are numerous causes of PLE, including [[Lymphangiectasia - WikiClinical|lymphangiectasia]], infectious causes, structural causes, neoplasia, [[Inflammation - Pathology|inflammation]], endoparasites and gastrointestinal [[Haemorrhage - Pathology|haemorrhage]].   
  
The major causes of PLE in adult dogs are [[Inflammatory Bowel Disease|inflammatory bowel disease (IBD)]], alimentary tract lymphoma, fungal infections (e.g. [[Systemic Mycoses #Histoplasmosis|histoplasmosis]]).  Other causes include ulcerations or erosions, severe disease of intestinal crypts and parasites.  The most common causes in very young dogs are [[Uncinaria stenocephala|hookworms]] and chronic intussusception.  Chronic intussusception results from acute enteritis which has not resolved completely.  The animal shows some clinical improvement but diarrhoea still continues.  PLE is less common in cats than dogs, and most often caused by alimentary tract lymphoma and IBD.  Cats almost never suffer from [[Lymphangiectasia - WikiClinical|lymphangiectasia]], and rarely have severe parasitic infection severe enough to cause PLE.  Non-intestinal diseases can be associated with PLE include ][[Pathophysiology of Heart Failure - Pathology|congestive heart failure]], caval obstruction and portal hypertension.  However, these animals usually present with ascites rather than [[Intestine Diarrhoea - Pathology|diarrhoea]].
+
The major causes of PLE in adult dogs are [[Inflammatory Bowel Disease|inflammatory bowel disease (IBD)]], alimentary tract lymphoma, fungal infections (e.g. [[Systemic Mycoses #Histoplasmosis|histoplasmosis]]).  Other causes include ulcerations or erosions, severe disease of intestinal crypts and parasites.  The most common causes in very young dogs are [[Uncinaria stenocephala|hookworms]] and chronic intussusception.  Chronic intussusception results from acute enteritis which has not resolved completely.  The animal shows some clinical improvement but diarrhoea still continues.  PLE is less common in cats than dogs, and most often caused by alimentary tract lymphoma and IBD.  Cats almost never suffer from [[Lymphangiectasia - WikiClinical|lymphangiectasia]], and rarely have severe parasitic infection severe enough to cause PLE.  Non-intestinal diseases can be associated with PLE include ][[Pathophysiology of Heart Failure - Pathology|congestive heart failure]], caval obstruction and portal hypertension.  However, these animals usually present with ascites rather than [[Diarrhoea|diarrhoea]].
  
 
==Diagnosis==
 
==Diagnosis==

Revision as of 19:22, 6 June 2010


Category:WikiClinical CanineCow
Category:WikiClinical FelineCow


Signalment

Breed predisposition:

  • Basenji
  • Lundehund
  • Soft-Coated Wheaten Terrier
  • Yorkshire Terrier
  • Shar Pei


Description

Protein-losing enteropathy (PLE) can result from any intestinal disease which produces sufficient inflammation, congestion or bleeding. This causes protein to leak into the intestines, which exceeds capacity of the gut lumen protein synthesis. Hence, there are numerous causes of PLE, including lymphangiectasia, infectious causes, structural causes, neoplasia, inflammation, endoparasites and gastrointestinal haemorrhage.

The major causes of PLE in adult dogs are inflammatory bowel disease (IBD), alimentary tract lymphoma, fungal infections (e.g. histoplasmosis). Other causes include ulcerations or erosions, severe disease of intestinal crypts and parasites. The most common causes in very young dogs are hookworms and chronic intussusception. Chronic intussusception results from acute enteritis which has not resolved completely. The animal shows some clinical improvement but diarrhoea still continues. PLE is less common in cats than dogs, and most often caused by alimentary tract lymphoma and IBD. Cats almost never suffer from lymphangiectasia, and rarely have severe parasitic infection severe enough to cause PLE. Non-intestinal diseases can be associated with PLE include ]congestive heart failure, caval obstruction and portal hypertension. However, these animals usually present with ascites rather than diarrhoea.

Diagnosis

Clinical Signs

  • Weight loss (predominant feature)
  • Vomiting and diarrhoea ± melena
  • Oedema, ascites and pleural effusion
  • Thickened intestines
  • Thromboembolic disease if procoagulants predominant due to loss of anticoagulant


Laboratory Tests

Haematology

  • Panhypoproteinaemia
    • Hepatic insufficiency and protein-losing nephropathy should also be pursued with hypoalbuminaemia.
  • Lymphopaenia

Biochemistry

Other Tests

  • Measurement of faecal loss alpha1-protease inhibitor


Diagnostic Imaging

Radiography

Ultrasonography

  • This may reveal thickening of intestines, mesenteric lymphadenopathy or abdominal effusion.


Histopathology

  • Endoscopically-guided multiple biopsies are useful. Surgical biopsy may be required for a definitive diagnosis of lymphoma and secondary lymphangiectasia. A small fatty meal could be given the night before biopsy to increase the chance of diagnosing lymphangiectasia.


Treatment

Plasma transfusion

  • This may be used to increase plasma volume. However, much of the albumin is lost in the gut and a substantial amount fails to remain in the intravascular compartment. Therefore, the extent of increase in serum albumin level is not great.
  • Administration of colloid may be more suitable if it is essential to increase the plasma oncotic pressure.

Diuretics

Prognosis

This depends on the underlying cause.

From Pathology

Protein-Losing Enteropathy (PLE)

  • Affects soft coated wheaten terriers.
    • Common male ancestor for most of the dogs.
    • Bitches are affected more often than dogs.
    • Also affects Besenji, Lundehund.
  • Normally, dietary protein and protein from shed enterocytes is almost completely absorbed.
    • In PLE there is excess loss of protein into the gut lumen.
      • The loss is non-selective i.e. albumin and globulin.
    • Causes panhypoproteinaemia and hypocholesterolaemia.
  • If this is severe, oedema and weight loss may result.
  • Enteropathy not due to gluten sensitivity.
  • Can diagnose PLE on basis of finding α1-protease inhibitor in the faeces in dogs.

Causes of PLE

  • Severe inflammatory disease.
    • Protein is lost in exudate.
  • Lymphangiectasia.
    • Loss of protein-rich lymph due to obstruction of gut lymphatics.
  • Increased mucosal permeability.
    • E.g. erosions, loss of tight junctions, lymphosarcoma.
  • Increased loss of enterocytes (less important).
  • Also:
    • Immunoproliferative enteropathy
    • Lymphocytic plasmacytic enteritis
    • Eosinophilic enteritis
    • GI ulceration/erosion
    • Giardiasis
    • Chronic intussusception
    • Small intestinal bacterial overgrowth
    • Neoplasia
    • Hypoalbunimaemia causing mural oedema
    • Increased activation of tissue plasminogen activator
    • Systemic lupus erythematosis (SLE)
    • Vascular lesion in the GI mucosa
    • Chemotherapy/radiotherapy.

Pathology

  • Lesions include:
    • Inflammatory bowel disease
    • Dilated lymphatics
    • Lipogranulomatous lymphangitis.
  • Intestinal crypts become dilated with mucus, sloughed epithelial cells with or without inflammatory cells.
  • PLE is also associated with protein losing nephropathy (PLN).
    • PLN may be a chronic sequelae to the PLE.
    • Follows immune complex deposition in the glomerulus, causing glomerulonephritis or glomerulosclerosis.
    • PLN causes hypoalbunaemian and hypercholesterolaemia.
    • Similar PLN and PLE lesions seen in young Besenjis with immunoproliferative enteropathy and glomerulosclerosis.


References

  • Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company.
  • Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA.
  • Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.
  • Willard, M. (2005) Protein-Losing Enteropathy in Dogs and Cats 30th World Congress of the WSAVA.