Difference between revisions of "Streptococcus & Enterococcus Infections - Pigs"
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| − | Also Known As | + | {{OpenPagesTop}} |
| + | Also Known As: '''''Bacterial Endocarditis –- Bacterial Pericarditis – Ear/Skin/Teat Necrosis – Streptococcal Pustules – Enterococcal Diarrhoea – Joint Ill – Jowl Abscess – Streptococcal Meningitis – Streptococcal Lymphadenitis – Streptococcosis – Streptococcal Otitis''''' | ||
| − | Caused By | + | Caused By: ''[[Streptococcus suis]] – S. bovis – S. dysgalactiae – S. hyointestinalis – S. intestinalis - S. porcinus - Enterococcus faecalis – E. durans'' |
==Introduction== | ==Introduction== | ||
| − | Streptoccocal and Enterococcal infections are '''common in pigs as the organisms are commensal''' in their | + | Streptoccocal and Enterococcal infections are '''common in pigs as the organisms are commensal''' in their gastrointestinal and reproductive tracts and environments. A multitude of diseases affecting many systems can be the result of infection with these organisms. |
| − | Most streptococcus species are opportunistic and the main precursor to ''S. suis | + | Most streptococcus species are opportunistic and the main precursor to ''S. suis'' infection in pigs is '''[[Porcine Reproductive and Respiratory Syndrome]]'''. |
''S. suis'' is also a '''zoonosis''' of significance which can cause severe disease in humans. | ''S. suis'' is also a '''zoonosis''' of significance which can cause severe disease in humans. | ||
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''S. suis'' '''capsular type 2''' is prevalent in almost all countries and is the organism of most importance from this group of pathogens. | ''S. suis'' '''capsular type 2''' is prevalent in almost all countries and is the organism of most importance from this group of pathogens. | ||
| − | ==Streptococcus suis Infection== | + | ==''Streptococcus suis'' Infection== |
===Signalment and Distribution=== | ===Signalment and Distribution=== | ||
The main host of ''S. suis'' is the domestic pig but cattle, sheep, goats, horses, dogs, cats and people can acquire the infection with varying clinical presentations. | The main host of ''S. suis'' is the domestic pig but cattle, sheep, goats, horses, dogs, cats and people can acquire the infection with varying clinical presentations. | ||
| − | It is a '''natural inhabitant of the respiratory, reproductive and gastrointestinal tracts'''. Disease usually occurs following '''movement of pigs between herds'' and is transmitted via the '''respiratory route''',<ref> Torremorell, M., Calsamiglia, M., Pijoan, C (1998) '''Colonization of suckling pigs by Streptococcus suis with particular reference to pathogenic serotype 2 strains'''. Canadian Journal of Veterinary Research, 62(1):21-26; 32</ref> '''during suckling''' and also '''vertically''' from infected sows to piglets.<ref> Amass, S. F., SanMiguel, P., Clark, L. K (1997) '''Demonstration of vertical transmission of Streptococcus suis in swine by genomic fingerprinting'''. J Clinical Microbiology, 35(6):1595-1959; 10</ref> | + | It is a '''natural inhabitant of the respiratory, reproductive and gastrointestinal tracts'''. Disease usually occurs following '''movement of pigs between herds'' and is transmitted via the '''respiratory route''',<ref> Torremorell, M., Calsamiglia, M., Pijoan, C (1998) '''Colonization of suckling pigs by Streptococcus suis with particular reference to pathogenic serotype 2 strains'''. ''Canadian Journal of Veterinary Research'', 62(1):21-26; 32</ref> '''during suckling''' and also '''vertically''' from infected sows to piglets.<ref> Amass, S. F., SanMiguel, P., Clark, L. K (1997) '''Demonstration of vertical transmission of Streptococcus suis in swine by genomic fingerprinting'''. ''J Clinical Microbiology'', 35(6):1595-1959; 10</ref> |
===Clinical Signs=== | ===Clinical Signs=== | ||
| − | Disease is often multisystemic and may involve the | + | Disease is often multisystemic and may involve the respiratory, neurological, cardiovascular, gastrointestinal systems and skin. '''The first sign is usually pyrexia. Peracute cases will be found dead''' with no premonitory signs. |
'''[[Pneumonia Overview|Pneumonia]]''' is a common presentation of infected pigs usually featuring '''coughing, sneezing, nasal discharge, epistaxis, tachypnoea, dyspnoea''' and a change in voice. | '''[[Pneumonia Overview|Pneumonia]]''' is a common presentation of infected pigs usually featuring '''coughing, sneezing, nasal discharge, epistaxis, tachypnoea, dyspnoea''' and a change in voice. | ||
| − | Pigs with streptococcal '''[[ | + | Pigs with streptococcal '''[[pericarditis]] or [[endocarditis]]''' are '''tachycardic, have muffled heart sounds and murmurs, are often ascitic and may exhibit jugular distension'''. Pulses may be weak, mucous membranes pale and an ECG often lacks P-waves and shows [[Arrhythmias Overview|dysrhythmmias]]. |
'''Meningitis''' is common and severe and may cause or be a consequence of '''otitis media'''. Ear infections may present as an '''aural discharge, deafness or scratching''' of the ears. The neurological disease features '''seizures, torticollis, head tilt, muscle spasms, paddling, tremors, paresis which many involve all four limbs, ataxia, hypermetria, irritability, depression, circling, head pressing and abnormal proprioception'''. Cranial nerve deficits may be seen and opthalmological signs may result. Pigs are often found dead and mortality may be significant. | '''Meningitis''' is common and severe and may cause or be a consequence of '''otitis media'''. Ear infections may present as an '''aural discharge, deafness or scratching''' of the ears. The neurological disease features '''seizures, torticollis, head tilt, muscle spasms, paddling, tremors, paresis which many involve all four limbs, ataxia, hypermetria, irritability, depression, circling, head pressing and abnormal proprioception'''. Cranial nerve deficits may be seen and opthalmological signs may result. Pigs are often found dead and mortality may be significant. | ||
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The [[Skin - Anatomy & Physiology|skin]] may be a route of entry for the pathogens or a later sign of systemic disease. '''Subcutaneous masses, abscesses and nodules may form and erythema, ulcers and sloughing''' can occur. The coat is often rough and “staring”. | The [[Skin - Anatomy & Physiology|skin]] may be a route of entry for the pathogens or a later sign of systemic disease. '''Subcutaneous masses, abscesses and nodules may form and erythema, ulcers and sloughing''' can occur. The coat is often rough and “staring”. | ||
| − | + | Reproductive disease can also result, causing '''agalactia, abortion and mastitis'''. | |
===Diagnosis=== | ===Diagnosis=== | ||
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It can be confirmed by '''isolation''' from tissues, joint fluid and cerebrospinal fluid, by '''PCR''' and serologically by '''[[ELISA testing|ELISA]]'''. | It can be confirmed by '''isolation''' from tissues, joint fluid and cerebrospinal fluid, by '''PCR''' and serologically by '''[[ELISA testing|ELISA]]'''. | ||
| − | On post-mortem, '''suppurative bronchopneumonia, neutrophilic meningitis/encephalitis and epicarditis''' are seen. Microscopic lesions are seen in the '''lung, brain, heart and joints'''. | + | On post-mortem, '''suppurative [[bronchopneumonia]], neutrophilic meningitis/encephalitis and epicarditis''' are seen. Microscopic lesions are seen in the '''lung, brain, heart and joints'''. |
===Treatment=== | ===Treatment=== | ||
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===''S. suis'' in humans=== | ===''S. suis'' in humans=== | ||
| − | Human cases of ''S. suis'' are '''infrequent but severe'''. '''Meningitis''' is the most common manifestation followed by '''septicaemia and endocarditis'''. The disease is often mistaken for other pathogens due to laboratories being unaware of its existence. | + | Human cases of ''S. suis'' are '''infrequent but severe'''. '''Meningitis''' is the most common manifestation followed by '''septicaemia and endocarditis'''. The disease is often mistaken for other pathogens due to laboratories being unaware of its existence. In most cases. ''S. suis'' capsular type 2 is responsible and disease is acquired through '''close contact''' with pigs or contaminated pork products,<ref>Elbers, A. R. W., Vecht, U., Osterhaus, A. D. M. E., Groen, J., Wisselink, H. J., Diepersloot, R. J. A., Tielen, M. J. M (1999) '''Low prevalence of antibodies against the zoonotic. agents Brucella abortus, Leptospira spp., Streptococcus suis serotype II, Hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of the Netherlands'''. ''Veterinary Quarterly'', 21(2):50-53; 51</ref> which enters through '''skin abrasions or cuts'''.<ref> Michaud, S., Duperval, R., Higgins, R (1996) '''Streptococcus suis meningitis: First case reported in Quebec'''. ''Canadian Journal of Infectious Diseases'', 7:329-331</ref>. |
==Other Species and Diseases== | ==Other Species and Diseases== | ||
===Enteritis=== | ===Enteritis=== | ||
| − | [[Diarrhoea]] is the primary sign associated with '''''Enterococcus spp.''''' infections, usually in '''neonatal pigs 2 -14 days old''' and commonly associated with '''''E. durans'''''. '''Mortality is usually low''', in contrast with other neonatal enteritis pathogens.<ref> Cheon, DooSung., Chae, Chanhee (1996) '''Outbreak of diarrhoea associated with Enterococcus durans in piglets'''. Journal Vet Diagnostic Investigation, 8(1):123-124; 8</ref> The condition can also affect calves and puppies. | + | [[Diarrhoea]] is the primary sign associated with '''''Enterococcus spp.''''' infections, usually in '''neonatal pigs 2 -14 days old''' and commonly associated with '''''E. durans'''''. '''Mortality is usually low''', in contrast with other neonatal enteritis pathogens.<ref> Cheon, DooSung., Chae, Chanhee (1996) '''Outbreak of diarrhoea associated with Enterococcus durans in piglets'''. ''Journal Vet Diagnostic Investigation'', 8(1):123-124; 8</ref> The condition can also affect calves and puppies. |
===Lymphadenitis=== | ===Lymphadenitis=== | ||
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Most disinfectants are active against ''S. suis'', but organic matter can reduce their efficacy so units should be pre-cleaned. | Most disinfectants are active against ''S. suis'', but organic matter can reduce their efficacy so units should be pre-cleaned. | ||
| − | '''Antibiotics''' can also be used prophylactically but the | + | '''Antibiotics''' can also be used prophylactically but the implications should always be considered. |
'''Vaccines''' are available but results are inconsistent. | '''Vaccines''' are available but results are inconsistent. | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
| − | + | {{CABI source | |
| + | |datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=63355&loadmodule=datasheet&page=2144&site=160 Streptococcus and Enterococcus infections in pigs (and ruminants)] | ||
| + | |date =4 July 2011 | ||
| + | }} | ||
| + | <br><br><br> | ||
| + | |||
| + | {{review}} | ||
| + | |||
| + | {{OpenPages}} | ||
| − | [[Category: | + | [[Category:CABI Expert Review]][[Category:CABI AHPC Pages]] [[Category:Respiratory Diseases - Pig]] [[Category: Cardiovascular Diseases - Pig]] [[Category:Dermatological Diseases - Pig]] [[Category:Neurological Diseases - Pig]] [[Category: Musculoskeletal Diseases - Pig]][[Category:Reproductive Diseases - Pig]] |
| + | [[Category:Zoonoses]] | ||
| + | [[Category:Cardiology Section]] | ||
Latest revision as of 17:22, 17 October 2013
Also Known As: Bacterial Endocarditis –- Bacterial Pericarditis – Ear/Skin/Teat Necrosis – Streptococcal Pustules – Enterococcal Diarrhoea – Joint Ill – Jowl Abscess – Streptococcal Meningitis – Streptococcal Lymphadenitis – Streptococcosis – Streptococcal Otitis
Caused By: Streptococcus suis – S. bovis – S. dysgalactiae – S. hyointestinalis – S. intestinalis - S. porcinus - Enterococcus faecalis – E. durans
Introduction
Streptoccocal and Enterococcal infections are common in pigs as the organisms are commensal in their gastrointestinal and reproductive tracts and environments. A multitude of diseases affecting many systems can be the result of infection with these organisms.
Most streptococcus species are opportunistic and the main precursor to S. suis infection in pigs is Porcine Reproductive and Respiratory Syndrome.
S. suis is also a zoonosis of significance which can cause severe disease in humans.
Distribution
These organisms are present worldwide due to their commensal nature.
S. suis capsular type 2 is prevalent in almost all countries and is the organism of most importance from this group of pathogens.
Streptococcus suis Infection
Signalment and Distribution
The main host of S. suis is the domestic pig but cattle, sheep, goats, horses, dogs, cats and people can acquire the infection with varying clinical presentations.
It is a natural inhabitant of the respiratory, reproductive and gastrointestinal tracts'. Disease usually occurs following movement of pigs between herds and is transmitted via the respiratory route,[1] during suckling and also vertically from infected sows to piglets.[2]
Clinical Signs
Disease is often multisystemic and may involve the respiratory, neurological, cardiovascular, gastrointestinal systems and skin. The first sign is usually pyrexia. Peracute cases will be found dead with no premonitory signs.
Pneumonia is a common presentation of infected pigs usually featuring coughing, sneezing, nasal discharge, epistaxis, tachypnoea, dyspnoea and a change in voice.
Pigs with streptococcal pericarditis or endocarditis are tachycardic, have muffled heart sounds and murmurs, are often ascitic and may exhibit jugular distension. Pulses may be weak, mucous membranes pale and an ECG often lacks P-waves and shows dysrhythmmias.
Meningitis is common and severe and may cause or be a consequence of otitis media. Ear infections may present as an aural discharge, deafness or scratching of the ears. The neurological disease features seizures, torticollis, head tilt, muscle spasms, paddling, tremors, paresis which many involve all four limbs, ataxia, hypermetria, irritability, depression, circling, head pressing and abnormal proprioception. Cranial nerve deficits may be seen and opthalmological signs may result. Pigs are often found dead and mortality may be significant.
If the organism enters the joints by direct or haematogenous routes, arthritis develops and leads to lameness, weakness and joint swelling, which may rupture and expose the purulent exudate. This is also a common consequence of navel infection in newborn pigs.
Enteritis is also commonly caused by S. suis and presents as anorexia, diarrhoea and dehydration.
The skin may be a route of entry for the pathogens or a later sign of systemic disease. Subcutaneous masses, abscesses and nodules may form and erythema, ulcers and sloughing can occur. The coat is often rough and “staring”.
Reproductive disease can also result, causing agalactia, abortion and mastitis.
Diagnosis
Diagnosis is often presumptive bases upon epidemiology, clinical signs and lesions seen at necropsy.
It can be confirmed by isolation from tissues, joint fluid and cerebrospinal fluid, by PCR and serologically by ELISA.
On post-mortem, suppurative bronchopneumonia, neutrophilic meningitis/encephalitis and epicarditis are seen. Microscopic lesions are seen in the lung, brain, heart and joints.
Treatment
Most S. suis isolates are susceptible to ampicillin and amoxicillin. Penicillin can also be used but resistance is slightly more common. Culture and sensitivity is recommended as a high degree of resistance to many antibiotics occurs. Anti-inflammatory therapy is also useful and advised.
S. suis in humans
Human cases of S. suis are infrequent but severe. Meningitis is the most common manifestation followed by septicaemia and endocarditis. The disease is often mistaken for other pathogens due to laboratories being unaware of its existence. In most cases. S. suis capsular type 2 is responsible and disease is acquired through close contact with pigs or contaminated pork products,[3] which enters through skin abrasions or cuts.[4].
Other Species and Diseases
Enteritis
Diarrhoea is the primary sign associated with Enterococcus spp. infections, usually in neonatal pigs 2 -14 days old and commonly associated with E. durans. Mortality is usually low, in contrast with other neonatal enteritis pathogens.[5] The condition can also affect calves and puppies.
Lymphadenitis
Streptococcal lymphadenitis is usually the result of infection with S. porcinus in growing pigs. Abscess formation is also a common feature of infection, forming on the jowl or in the cervical region. This is the result of dissemination of infection from its initial location in the pharynx and tonsils. Infection can be transmitted via ingestion of abscess exudates/contents or infected faeces, by direct contact or via drinking water. This disease is of particular economic importance in the USA. It can be diagnosed by isolation from tonsils, pharynx, nasal cavity and vagina/prepuce. S. porcinus is often isolated from pneumonia, enteritis and arthritis cases also, but is thought to be secondary in these situations. This disease is not zoonotic.
Control
Minimising stock density, keeping stress minimal and environmental conditions consistent can help to reduce the prevalence and transmission of infection. Pigs with an age difference of more than two weeks should not be mixed. All-in/all-out systems are ideal.
Most disinfectants are active against S. suis, but organic matter can reduce their efficacy so units should be pre-cleaned.
Antibiotics can also be used prophylactically but the implications should always be considered.
Vaccines are available but results are inconsistent.
| Streptococcus & Enterococcus Infections - Pigs Learning Resources | |
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Streptococcus and Enterococcus Infections in Pigs Flashcards |
References
- ↑ Torremorell, M., Calsamiglia, M., Pijoan, C (1998) Colonization of suckling pigs by Streptococcus suis with particular reference to pathogenic serotype 2 strains. Canadian Journal of Veterinary Research, 62(1):21-26; 32
- ↑ Amass, S. F., SanMiguel, P., Clark, L. K (1997) Demonstration of vertical transmission of Streptococcus suis in swine by genomic fingerprinting. J Clinical Microbiology, 35(6):1595-1959; 10
- ↑ Elbers, A. R. W., Vecht, U., Osterhaus, A. D. M. E., Groen, J., Wisselink, H. J., Diepersloot, R. J. A., Tielen, M. J. M (1999) Low prevalence of antibodies against the zoonotic. agents Brucella abortus, Leptospira spp., Streptococcus suis serotype II, Hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of the Netherlands. Veterinary Quarterly, 21(2):50-53; 51
- ↑ Michaud, S., Duperval, R., Higgins, R (1996) Streptococcus suis meningitis: First case reported in Quebec. Canadian Journal of Infectious Diseases, 7:329-331
- ↑ Cheon, DooSung., Chae, Chanhee (1996) Outbreak of diarrhoea associated with Enterococcus durans in piglets. Journal Vet Diagnostic Investigation, 8(1):123-124; 8
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This article was originally sourced from The Animal Health & Production Compendium (AHPC) published online by CABI during the OVAL Project. The datasheet was accessed on 4 July 2011. |
 |
This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |
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