Changes

[[Image:B-cell immunity.jpg|thumb|right|250pxl|B-cell differentiation - B. Catchpole, RVC 2008]]

[[Image:B-cell immunity.jpg|thumb|right|250pxl|B-cell differentiation - B. Catchpole, RVC 2008]]

==Introduction==

==Introduction==

===Class switching===

===Class switching===

<p>Initially plasma cell produce [[Immunoglobulin M|Immunoglobulin M (IgM)]] however this is not always the most appropriate Ig to be produced and therefore stimulation by [[Lymphocytes#Helper CD4+|T cells]] and interleukins causes the plasma cells to undergo class switching to produce different classes of Immunoglobulins.

<p>Initially plasma cell produce [[Immunoglobulin M|Immunoglobulin M (IgM)]] however this is not always the most appropriate Ig to be produced and therefore stimulation by [[Lymphocytes#Helper CD4+|T cells]] and interleukins causes the plasma cells to undergo class switching to produce different classes of Immunoglobulins.

*In mucosal B cells plasma cells CD40 interaction (with TH₂ CD40L) and Il-10 stimulates class switching to [[Immunoglobulin A|IgA]]

*In mucosal B cells plasma cells CD40 interaction (with T_H2 CD40L) and Il-10 stimulates class switching to [[Immunoglobulin A|IgA]]

*[[Eosinophils|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E|IgE]]</p>

*[[Eosinophils|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E|IgE]]</p>

<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G|IgG]] class.</p>

<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G|IgG]] class.</p>

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{{Jim Bee 2007}}

{{Jim Bee 2007}}

[[Category:Lymphocytes|C]]

[[Category:Lymphocytes|C]]

[[Category:Adaptive Immune System]]

[[Category:Adaptive Immune System]]