Difference between revisions of "Respiratory Fungal Infections - Pathology"
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| + | |backcolour = D1EEEE | ||
| + | |linkpage =Cardiorespiratory System - Pathology | ||
| + | |linktext =Cardiorespiratory System | ||
| + | |maplink = Cardiorespiratory System (Content Map) - Pathology | ||
| + | |pagetype =Pathology | ||
| + | |sublink1=Respiratory System Inflammation - Pathology | ||
| + | |subtext1=RESPIRATORY SYSTEM INFLAMMATION | ||
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| + | <br> | ||
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| + | [[Aspergillosis]] | ||
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| + | ===''Cryptococcus neoformans''=== | ||
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| + | *[[Yeast-like fungi|''Cryptococcus neoformans'']] | ||
| + | *Causes a [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|granulomatous rhinitis]], gelatinous exudate, [[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous pneumonia]] | ||
| + | *Nodules or destructive masses which often result in facial swelling | ||
| + | *In severe cases, extension from nasal cavity to involve skin and oral mucosa can occur | ||
| + | *Can invade through adjacent structures, eg: through the cribiform plate into the brain! These cases therefore can present as a primary neurological disease. | ||
| + | *Microscopic: | ||
| + | **Large number of fungi and only few macrophages, lymphocytes and giant cells | ||
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| + | ===Blastomycosis=== | ||
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| + | *Caused by [[Yeast-like fungi|''Blastomyces dermatitidis'']] | ||
| + | *Occurs mainly in the Americas, Middle East and Africa, occasionally in Europe | ||
| + | *Mainly in young dogs, occasionally other species | ||
| + | *Can involve almost any tissue after spread from lungs | ||
| + | *Gross lesions: | ||
| + | **[[Lungs Inflammatory - Pathology#Granulomatous pneumonia|Granulomatous pneumonia]] | ||
| + | *Microscopic lesions: | ||
| + | **Yeast fungi with thich walls in nodules with macrophages, [[Neutrophils|neutrophils]] and giant cells | ||
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| + | ===Histoplasmosis=== | ||
| + | |||
| + | *Caused by [[Yeast-like fungi|''Histoplasma capsulatum'']] | ||
| + | *Gross lesions in lungs: | ||
| + | **Firm encapsulated granulomas ([[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous pneumonia]]) | ||
| + | *Microscopic lesions: | ||
| + | **Macrophages with inracytoplasmic yeasts | ||
| + | *Also in other tissues | ||
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| + | ===[[Fungi|''Pneumocystis carinii'']]=== | ||
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| + | *Important cause of pneumonia in humans associated with immunodeficiency states | ||
| + | *It has been occasionally reported in young or immunosuppressed animals (e.g. Arabian foals with congenital immunodeficiency) | ||
| + | *Grossly: | ||
| + | **Diffuse [[Lungs Inflammatory - Pathology#Interstitial pneumonia|interstitial]] [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]] | ||
| + | **Patches of firmness or consolidation | ||
| + | *Histologically: | ||
| + | **Alveoli are filled with pale staining acidophilic material (= trophozoite and cyst forms of the organism) | ||
| + | *It is thought that as P. carinii is often present as a latent infection, alveolar macrophages normally control the organism - a process which fails in immunodeficient states | ||
Revision as of 14:28, 30 June 2010
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Cryptococcus neoformans
- Cryptococcus neoformans
- Causes a granulomatous rhinitis, gelatinous exudate, granulomatous pneumonia
- Nodules or destructive masses which often result in facial swelling
- In severe cases, extension from nasal cavity to involve skin and oral mucosa can occur
- Can invade through adjacent structures, eg: through the cribiform plate into the brain! These cases therefore can present as a primary neurological disease.
- Microscopic:
- Large number of fungi and only few macrophages, lymphocytes and giant cells
Blastomycosis
- Caused by Blastomyces dermatitidis
- Occurs mainly in the Americas, Middle East and Africa, occasionally in Europe
- Mainly in young dogs, occasionally other species
- Can involve almost any tissue after spread from lungs
- Gross lesions:
- Microscopic lesions:
- Yeast fungi with thich walls in nodules with macrophages, neutrophils and giant cells
Histoplasmosis
- Caused by Histoplasma capsulatum
- Gross lesions in lungs:
- Firm encapsulated granulomas (granulomatous pneumonia)
- Microscopic lesions:
- Macrophages with inracytoplasmic yeasts
- Also in other tissues
Pneumocystis carinii
- Important cause of pneumonia in humans associated with immunodeficiency states
- It has been occasionally reported in young or immunosuppressed animals (e.g. Arabian foals with congenital immunodeficiency)
- Grossly:
- Diffuse interstitial pneumonia
- Patches of firmness or consolidation
- Histologically:
- Alveoli are filled with pale staining acidophilic material (= trophozoite and cyst forms of the organism)
- It is thought that as P. carinii is often present as a latent infection, alveolar macrophages normally control the organism - a process which fails in immunodeficient states