Difference between revisions of "Lymphopenia"

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* Lymphopenia is a redcution in the numbers of lymphocytes in the blood.
 
  
* Occurs in:
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==Introduction==
** Viruses that attack the lymphoid system.
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Lymphopenia is a reduction in the numbers of lymphocytes in the blood.  This phenomenon is most commonly associated with stress (as part of the '''stress leucogram''') or with viral infection.  Causes include:
*** For example:
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*[[Stress Leucogram|Stress leucogram]], characterised by '''[[Neutrophilia|neutrophilia]]''', '''[[Monocytosis|monocytosis]]''', '''[[Eosinopenia|eosinopenia]]''' and '''[[Lymphopenia|lymphopenia]]'''.  A similar pattern may occur with hyperadrenocorticism (Cushing’s disease) or exogenous corticosteroid therapy as these hormones selectively suppress lymphocytic activity and the inflammatory response in general.
**** [[Paramyxoviridae#Canine Distemper Virus (CDV)|Canine Distemper]]
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*Viral infection with [[Canine Distemper Virus|canine distemper]], [[Infectious Canine Hepatitis|Infectious canine hepatitis]], [[Feline infectious enteritis|feline infectious enteritis]] or [[Bovine Viral Diarrhoea|bovine viral diarrhoea]] (BVD)
**** Infectious Canine Hepatitis
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*Bone marrow suppression caused by '''chemotherapy''' or '''radiotherapy'''.  Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia.
**** Feline Infectious Enteritis
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*Inherited or acquired immunodeficiency syndromes, including '''[[Equine Severe Combined Immune Deficiency|SCID]]''' (Severe Combined Immunodeficiency Syndrome) in Arab foals and [[Feline Immunodeficiency Virus|'''feline immunodeficiency virus''']] infection.
**** Bovine Virus Diarrhoea.
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*Leakage of lymphatic fluid may result in loss of lymphocytes, as occurs with '''[[Lymphangiectasia|lymphangiectasia]]''' or '''[[Chylous Effusion|chylothorax]]'''.
** Irradiation
 
** Corticosteroid therapy.
 
*** Selectively suppresses lymphocytic activity, and the inflammatory response in general.
 
  
*** Other immunosuppressive drugs may act in a similar way.
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{{Learning
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|literature search = [http://www.cabdirect.org/search.html?it=any&q2=lymphopaenia&q1=lymphopenia&calendarInput=yyyy-mm-dd&occuring1=title&show=all&rowId=1&rowId=2&rowId=3&options1=AND&options2=OR&options3=AND&occuring3=freetext&occuring2=title&publishedend=yyyy&la=any&publishedstart=yyyy&fq=sc%3A%22ve%22&y=6&x=40 Publications with 'lymphopenia' in their title]
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}}
  
[[Category:Haematology Changes]][[Category:To Do - James]]
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{{review}}
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==Webinars==
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<rss max="10" highlight="none">https://www.thewebinarvet.com/clinical-pathology/webinars/feed</rss>
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[[Category:Haematology Changes]][[Category:Expert Review]][[Category:Bullet Points]]

Latest revision as of 16:23, 5 January 2023

Introduction

Lymphopenia is a reduction in the numbers of lymphocytes in the blood. This phenomenon is most commonly associated with stress (as part of the stress leucogram) or with viral infection. Causes include:


Lymphopenia Learning Resources
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