Difference between revisions of "Lymphopenia"
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==Description== | ==Description== | ||
Lymphopenia is a reduction in the numbers of lymphocytes in the blood. This phenomenon is most commonly associated with stress (as part of the '''stress leucogram''') or with viral infection. Causes include: | Lymphopenia is a reduction in the numbers of lymphocytes in the blood. This phenomenon is most commonly associated with stress (as part of the '''stress leucogram''') or with viral infection. Causes include: | ||
| + | *Stress leucogram, characterised by '''[[Neutrophilia|neutrophilia]]''', '''[[Monocytosis|monocytosis]]''', '''[[Eosinopenia|eosinopenia]]''' and '''[[Lymphopenia|lymphopenia]]'''. A similar pattern may occur with hyperadrenocorticism (Cushing’s disease) or exogenous corticosteroid therapy as these hormones selectively suppress lymphocytic activity and the inflammatory response in general. | ||
*Viral infection with [[Canine Distemper Virus|canine distemper]], [[Infectious canine hepatitis]], [[Feline infectious enteritis|feline infectious enteritis]] or [[Bovine Viral Diarrhoea|bovine viral diarrhoea]] (BVD) | *Viral infection with [[Canine Distemper Virus|canine distemper]], [[Infectious canine hepatitis]], [[Feline infectious enteritis|feline infectious enteritis]] or [[Bovine Viral Diarrhoea|bovine viral diarrhoea]] (BVD) | ||
*Bone marrow suppression caused by '''chemotherapy''' or '''radiotherapy'''. Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia. | *Bone marrow suppression caused by '''chemotherapy''' or '''radiotherapy'''. Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia. | ||
*Inherited or acquired immunodeficiency syndromes, including '''[[Equine Severe Combined Immune Deficiency|SCID]]''' (Severe Combined Immunodeficiency Syndrome) in Arab foals and [[Feline Immunodeficiency Virus|'''feline immunodeficiency virus''']] infection. | *Inherited or acquired immunodeficiency syndromes, including '''[[Equine Severe Combined Immune Deficiency|SCID]]''' (Severe Combined Immunodeficiency Syndrome) in Arab foals and [[Feline Immunodeficiency Virus|'''feline immunodeficiency virus''']] infection. | ||
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*Leakage of lymphatic fluid may result in loss of lymphocytes, as occurs with '''[[Lymphangiectasia|lymphangiectasia]]''' or '''[[Chylous Effusion|chylothorax]]'''. | *Leakage of lymphatic fluid may result in loss of lymphocytes, as occurs with '''[[Lymphangiectasia|lymphangiectasia]]''' or '''[[Chylous Effusion|chylothorax]]'''. | ||
Revision as of 17:23, 1 November 2010
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Description
Lymphopenia is a reduction in the numbers of lymphocytes in the blood. This phenomenon is most commonly associated with stress (as part of the stress leucogram) or with viral infection. Causes include:
- Stress leucogram, characterised by neutrophilia, monocytosis, eosinopenia and lymphopenia. A similar pattern may occur with hyperadrenocorticism (Cushing’s disease) or exogenous corticosteroid therapy as these hormones selectively suppress lymphocytic activity and the inflammatory response in general.
- Viral infection with canine distemper, Infectious canine hepatitis, feline infectious enteritis or bovine viral diarrhoea (BVD)
- Bone marrow suppression caused by chemotherapy or radiotherapy. Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia.
- Inherited or acquired immunodeficiency syndromes, including SCID (Severe Combined Immunodeficiency Syndrome) in Arab foals and feline immunodeficiency virus infection.
- Leakage of lymphatic fluid may result in loss of lymphocytes, as occurs with lymphangiectasia or chylothorax.
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Publications with 'lymphopenia' in their title