Omega-6 Fatty Acids - Nutrition
What are Omega-6 Fatty Acids?
Omega-6 fatty acids are a family of polyunsaturated straight-chain hydrocarbons that have a double bond in the sixth carbon-carbon bond (n-6) when counted from the methyl end of the molecule. Linoleic acid contains 18 carbons with double bonds at both the n-6 and n-9 positions (written as 18:2n-6). It undergoes further desaturation by hepatic Δ-6 desaturase to form gamma-linolenic acid (GLA; 18:3n-6), which is elongated and desaturated once more to form arachidonic acid (AA; 20:4n-6). Linoleic acid (LA) is considered an essential fatty acid in both dogs and cats. Dogs are able to convert adequate amounts of LA to AA to meet requirements at all life-stages, cats however have limited hepatic Δ-6 desaturase enzyme activity and require a dietary source of AA to meet their metabolic needs. The dietary requirement for LA in cats is lower than dogs because LA is not used as a precursor for synthesis of AA.
Why are they Important?
Linoleic acid is concentrated in the skin and hair coat of cats and dogs to form the normal water permeable barrier of the epidermis. Arachidonic acid is incorporated into the lipid bilayer of all cell membranes; it serves both as a structural component of cell walls and a precursor to normal inflammatory mediators. Increased intake of LA above the minimal requirement may help improve skin and coat quality in dogs and cats. Modification of AA intake in relation to specific omega-3 fatty acids has been suggested as an aid in the management of inflammatory condition (such as allergic dermatitis, nephritis, or inflammatory bowel disease) in dogs and cats. Omega-6 and omega-3 fatty acids compete for the same metabolic enzymes; as such the total amount as well as the ratio of omega-6 to omega-3 fatty acids is an important consideration when evaluating dietary balance or when attempting to modify concentrations of these nutrients for health and disease management.
Roles in the Body
- Skin and Hair Coat: Epidermal keratinocytes secrete the LA-enriched phospholipid, ceramide, in both dogs and cats. Ceramide functions to enhance cell cohesion and create an effective water barrier. Increased intake of LA above the minimal requirement may improve skin and coat health in dogs and cats.
- Inflammation: Arachidonic acid comprises approximately 20-25% of the fatty acids within the cellular membrane and acts as a substrate for cyclooxygenase (COX) and lipoxygenase (LOX) enzymes to form the inflammatory eicosanoids series-2 prostaglandins (prostaglandins, prostycyclins and thromboxanes) and series-4 leukotrienes.
- Reproduction: Queens fed AA deficient diets with adequate levels of LA are unable to support normal pregnancy and foetal development, while no impact on male fertility and spermatogenesis is seen.
Consequences of Omega-6 Fatty Acid Deficiency
- Growth: Kittens fed LA deficient diets fail to grow normally and develop course dull hair coats. Puppies fed a LA deficient diet developed coarse, dry hair coats with skin flaking after 2 months.
- Maintenance: When fed a LA deficient diet, increased endogenous production of oleic acid (18:1n-9) occurs. Oleic acid is incorporated into ceramide in place of the missing LA, but is less effective at maintaining cell cohesion. Thickening of the epidermis and cellular swelling occur, and the thickened more loosely packed keratinocytes slough readily resulting in the clinical appearance of scaling. The greasy, flaky skin is prone to secondary infection and pyoderma occurs commonly with LA deficiencies. Interdigital exudation and otitis externa are also sequelae of LA deficiencies in dogs. There are no clinical signs reported with AA deficiency in adult, non-reproductive cats.
- Reproduction: Linoleic acid deficiency does not appear to impact reproduction in dogs and cats, but AA deficiency in queens does not support normal pregnancy or foetal development. Queens fed AA deficient diets from weaning will have normal heat cycles and may have a single litters of kittens, but are unable to support further pregnancies.
There is speculation that increased intake of omega-6 fatty acids with inadequate omega-3 fatty acids intake may promote a pro-inflammatory state, but research evidence to support this is lacking in dogs and cats.
Depending on what is fed during production, animal fats (associated with muscle meat, organ meat, and eggs) have varying LA concentrations; animal fats are good sources of AA. Seed and seed oils are more consistent sources of LA. Corn, soy and cottonseed oils have the highest concentrations of LA (approximately 50% of the total fat), while other seed oils are must lower such as flaxseed at 12% LA. Many seed oil crops are also being modified for human health concerns and even those with historically higher levels of LA are being modified to produce less LA and more oleic acid or alpha-linolenic acid. Sunflower oil is an example of this genetic modification. Sunflower oil naturally contains close to 65% linoleic acid content but new genetically modified strains are high in oleic acid with only 3% linoleic acid. Commercial pet food companies monitor levels of essential omega-6 fatty acids in source ingredients, but care must be taken when selecting essential fatty acid sources for home-prepared diets.
Diagnosing Omega-6 Fatty Acid Deficiency
Diagnosis based on compatible clinical signs of LA deficiency and evaluation of diet. Plasma lipid profiles can also be used to diagnose LA deficiencies; increased concentrations of the omega-9 fatty acid oleic acid (18:1n-9) are also seen with LA deficiency. Arachidonic acid deficiency in reproductive queens is difficult to determine and often relies on evaluation of diet.
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Date reviewed: 19 May 2015
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